KIM-1在扩张型心肌病心力衰竭患者中肾功能的评估作用  

The role of KIM-1 in the evaluation of renal function of patients with dilated cardiomyopathy heart failure

作　　者：陶建平[1] 魏盟[1] 陈忠[1] TAO Jian- ping WEI Meng CHEN Zhong(Department of Cardiology ,the Sixth Hospital of Shanghai, Shanghai 200233, Chin)

机构地区：[1]上海市第六人民医院心内科,上海200233

出　　处：《现代医学》2016年第9期1278-1281,共4页Modern Medical Journal

摘　　要：目的:研究肾损伤分子1(KIM-1)在扩张型心肌病(DCM)心力衰竭患者中肾功能的评估作用。方法:入选DCM心力衰竭患者68例以及同一年龄段的健康对照组68例,行超声心动图检查,检测血清肌酐、pro-BNP、尿中KIM-1的浓度,研究两组的pro-BNP、左心室射血分数(LVEF)、肌酐清除率(Ccr)、尿KIM-1变化情况。结果:与对照组相比,心衰组LVEF、Ccr明显降低,pro-BNP、KIM-1明显升高(P<0.05);心衰组中,随着心衰症状加重LVEF明显降低,pro-BNP、KIM-1明显升高(P<0.05),Ccr虽有降低,但差异无统计学意义(P>0.05);心衰组KIM-1与pro-BNP、LVEF、Ccr均明显相关(r=0.831、-0.728、-0.677,P<0.01)。结论:KIM-1能较早地反映DCM心力衰竭患者的肾功能损伤,对心力衰竭患者的病情评估、预后判断有较大价值。Objective： To evaluate the value of kidney injury molecule-1（ KIM-1） on renal function with dilated cardiomyopathy heart failure（ DHF）. Methods： 68 patients with DHF were enrolled into the DHF group,68 agematched healthy people as control group. Creatinine clearance rate（ Ccr）,pro-BNP,urinary KIM-1 and left ventricular ejection fraction（ LVEF） were detected and analyzed between DHF group and control group. Results：Ccr and LVEF were lower in the DHF group than those in the control group,but pro-BNP and KIM-1 were higher in the DHF group（ P〈0. 05）. Along with the aggravation of heart failure symptoms,LVEF gradually decreased,proBNP and KIM-1 increased significantly（ P〈0. 05）,Ccr didn＇t decrease significantly（ P〉0. 05）,even though Ccr decreased gradually. There was correlation betwen KIM-1 and pro-BNP,LVEF,Ccr in DHF group（ r = 0. 831,- 0. 728,- 0. 677,P〈0. 01）. Conclusion： KIM-1 reflects the early renal function injury in patients with haert failure,and has great value in assessing the condition and prognosis of patients with heart faiure.

关 键 词：肾损伤分子1 扩张型心肌病 心力衰竭 

分 类 号：R542.2[医药卫生—心血管疾病] R541.6[医药卫生—内科学]