元胡止痛胃漂浮型控释片初步研究  

Preliminary study on preparation of Yuanhuzhitong HBS Tablet

作　　者：胡志方 朱卫丰[2] 郭慧玲 

机构地区：[1]江西中医学院附属医院,江西南昌330006 [2]江西中医学院中药制药研究中心,江西南昌330006 [3]江西制药有限责任公司,江西南昌330006

出　　处：《中成药》2002年第8期573-575,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨元胡止痛片剂型改进为胃漂浮型控释片的制备工艺及质量控制方法。方法 :筛选漂浮型成型辅料 ,并选用延胡索乙素作为对照品 ,采用薄层层析—紫外分光光度法进行含量测定。结果 :供试品起漂时间为 1～ 3min ;主要有效成分延胡索乙素 3h相对溶出度为 32 % ,9h相对溶出度为 86 % ;初步制订质量控制方法。结论 :为制备元胡止痛胃漂浮片提供依据。Objective: To study the preparation and quality control methods of Yuanhu Zhitong HBS Tablet. Methods: the suitable excipients and formulation process of Yuanhu Zhitong HBS Tablet is sieved by means of testing quantity of tetrahydropalmatine through TLC UV. Results: the beginning floating time of HBS Tablet is 3min; relative dissolution of main component tetrahydropalmatine is 32% within 3hr, 86% within 9 hr. Conclusions: the study is found to be effective in the process of Yuanhu Zhitong HBS Tablet.

关 键 词：胃漂浮型控释片 元胡止痛片 制备工艺 质量控制 薄层层析-紫外分光光度法 含量测定 

分 类 号：R283.617[医药卫生—中药学] TQ461[医药卫生—中医学]