NT-pro BNP在AECOPD患者心功能和预后评价中的应用  

Application of BNP NT-pro in the evaluation of cardiac function and prognosis of patients with AECOPD

作　　者：杨继俊 叶世华[1] 梁宇[1] 潘利英[1] YANG Ji-jun YE Shi-hua LIANG Yu PAN Li-ying(Department of lnternal Medicine, Dongguan Huangjiang Hospital, Dongguan, Guangdong 523750, Chin)

机构地区：[1]东莞市黄江医院内一科,广东东莞523750

出　　处：《临床肺科杂志》2017年第3期439-442,共4页Journal of Clinical Pulmonary Medicine

基　　金：广东省东莞市科技计划项目(No 2016105101212)

摘　　要：目的探讨脑钠肽前体(NT-pro BNP)水平对AECOPD患者心脏功能和预后的评价价值。方法 2015年6月-2016年6月在我院接受治疗的AECOPD患者为观察对象。根据NT-pro BNP水平将其分为NT-pro BNP升高组和NT-pro BNP正常组。观察两组患者肺功能和心功能指标的差异,比较两组患者预后的差异。结果 NT-pro BNP升高组患者的FVC、FEV_1和PEF等肺功能指标低于NT-pro BNP正常组,差异具有统计学意义(P<0.05);NT-pro BNP升高组患者的LAD、RAD、LVESD和LVEDD水平高于NT-pro BNP正常组,而LVEF水平低于NT-pro BNP正常组,差异具有统计学意义(P<0.05);NT-pro BNP水平与LAD、RAD、LVESD和LVEDD正相关,与LVEF负相关(P<0.05);NT-pro BNP正常组生活质量得分明显优于NT-pro BNP升高组,差异具有统计学意义。结论 NT-pro BNP水平对AECOPD患者的心功能和预后有较好的评价价值,可作为临床监测的重要指标。Objective To evaluate the value of BNP NT-pro level in the evaluation of cardiac function and prognosis of patients with AECOPD. Methods AECOPD patients treated in our hospital from June 2015 to June 2016 were treated selected as the observation objects. According to BNP NT-pro level, they were divided into the high BNP NT-pro group and the normal BNP NT-pro group. The differences of lung function and heart function index between the two groups were observed, and the difference of prognosis were compared. Results The levels of FVC, FEV1 and PEF in the high BNP NT-pro group were lower than those in the normal group （P 〈 0. 05 ）. The levels of LVEDD, RAD and LVESD -pro were higher in the high group than in the normal group, and the level of LVEF was lower in the high group than in the normal group （ P 〈 0.05 ）. BNP NT-pro level was positively correlated with LAD, RAD, LVESD and LVEDD, and negatively correlated with LVEF （ P 〈 0. 05 ）. The quality of life in the normal NT- pro BNP group was signifieantly better than that in the high BNP NT-pro group. Conclusion The level of BNP NT- pro has a good value in evaluating the cardiac function and prognosis of AECOPD patients, and it can be used as an important indicator for clinical monitoring.

关 键 词：脑钠肽前体 慢性阻塞性肺疾病急性加重期 心功能 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]