肺康复对老年慢性阻塞性肺疾病稳定期患者血清炎症因子的影响  

Effect of pulmonary rehabilitation on serum inflammatory factors of elderly patients with stable chronic obstructive pulmonary disease

作　　者：陈节[1] 孙红梅[1] CHEN Jie SUN Hong-mei(Huaxi Hospital of Sichuan University, Chengdu, Sichuan 610000, China)

机构地区：[1]四川大学华西医院干部医疗科,四川成都610000

出　　处：《临床肺科杂志》2017年第3期464-467,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨肺康复对老年慢性阻塞性肺疾病稳定期患者临床疗效、肺部功能、运动耐力与血清炎症因子的影响效果。方法收集2015年2月至2016年2月入院的80例慢性阻塞性肺疾病稳定期老年患者随机分为两组,对照组患者给予传统内科药物治疗,实验组患者则加施肺康复干预,比较两组患者整体治疗效果、治疗前后呼吸困难情况、肺功能、运动耐力与炎症因子水平。结果实验组患者整体治疗总有效率明显高于对照组,治疗后呼吸困难情况组间比较明显优于对照组,存在明显差异,具有统计学意义(P<0.05);实验组患者治疗后FVC、FEV_1、FEV_1/FVC与6MWT水平组间比较均显著性高于对照组,CRP、Fbg、IL-6、IL-8、IL-10与TNF-α水平组间比较均显著性低于对照组,存在显著性差异,具有统计学意义(P<0.01)。结论肺康复对老年慢性阻塞性肺疾病稳定期患者临床疗效、肺部功能、运动耐力与血清炎症因子的影响效果显著,对临床有借鉴意义。Objective To investigate the clinical efficacy of pulmonary rehabilitation on serum inflammatory factors of elderly patients with stable chronic obstructive pulmonary disease. Methods February 2015 to February 2016, 80 hospitalized elderly patients with chronic obstructive pulmonary disease were randomly divided into two groups. The control group was treated with conventional medical therapy, and the experimental group was then ap- plied on pulmonary rehabilitation interventions. Their breathing difficulties, lung function, exercise tolerance and in- flammatory cytokine levels were compared before and after treatment. Results The total effective rate was signifi- cantly higher in the experiment group than in the control group after treatment （P 〈 0. 05 ）, and dyspnea improved more obviously in the experiment group than in the control group after treatment. The value of FVC, FEV1, FEV1/ FVC and 6MWT was significantly higher in the experiment group than in the control group, and the value of CRP, Fbg, IL-6, IL-8, IL-10 and TNF-α were significantly lower in the experiment group than in the control group （P 〈 0. 01）. Conclusion Pulmonary rehabilitation can improve their clinical efficacy, lung function, exercise tolerance and have obvious effect on serum inflammatory factors in treatment of elderly patients with stable COPD.

关 键 词：肺康复 慢性阻塞性肺疾病稳定期 肺功 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统]