双红通治疗糖尿病周围神经病变的临床观察与实验研究  

Study of the effect of Shuanghongtong Decoction on diabetic neuropathy peripheral

作　　者：陈剑秋[1] 石志芸[1] 王文健 薛红丽 陈伟华 

机构地区：[1]上海复旦大学附属华山医院中医科,上海200040

出　　处：《中成药》2002年第8期601-604,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :观察双红通 (红花、红参、麦冬 ,等 )对糖尿病周围神经病变 (DPN)的疗效并探讨其作用机制。方法 :2 8例糖尿病周围神经病变患者 ,观察双红通治疗前后症状以及神经电生理变化。对链脲佐菌素 (STZ)诱导的DPN大鼠给予同样药物治疗 ,4周后测定肌电图 ,红细胞醛糖还原酶活性。结果 :治疗后DPN患者肢端疼痛、麻木、无力改善率分别达 80 .9% ,73.7% ,76 % ,感觉神经传导速度增快 ,与治疗前比较 ,有差异显著性 (P <0 .0 5 )。动物实验提示 :经双红通治疗后 ,糖尿病大鼠的神经传导速度明显加快 ,醛糖还原酶活性明显降低 ,与对照组相比差异有统计学意义。 (P <0 .0 5 )。结论 :双红通能改善临床症状 ,增快神经传导速度 ,其作用机制并非通过降低血糖 ,而是抑制醛糖还原酶活性 ,从而达到减轻神经损伤和改善病情。Objective: To investigate the curative effects of Shuanghongtong Decoction (Flos carthami, Radix Ginseng Rubra and Radix Ophiopogonis) diabetic neuropathy peripheral (DPN) and its mechanism.Methods:28 DPN patients were treated with Shuanghongtong Decoction for 3 weeks. The symptom and the peroneal nerve conduction velocity (SNCV) were observed before and after the experiments respectively. The diabetic rats reduced by STZ were treated with the same decoction for 4 weeks, at the end of the experiments the nerve conduction velocity (NCV) and the activity of aldose reductase (AR) were measured.Results: Some symptoms such as acra pain, numbness, asthenia and the peroneal SNCV were significantly improved after treatment with decoction. The animal experiments showed that the NCV were significantly increased and the activity of AR significantly decreased in diabetic rats as compared with the normal rats.Conclusion: Shuanghongtong Decoction could improve the symptom and increase the NCV of DPN. It's mechanism may be through inhibiting the activity of AR then improving the diabetic metabolism disorder.

关 键 词：临床观察 实验研究 双红通 糖尿病周围神经病变 中医药疗法 红细胞醛糖还原酶 

分 类 号：R259.872[医药卫生—中西医结合] R286.715[医药卫生—中医内科学]