御风胶囊对缺血再灌注大鼠脑组织ATPase活性保护作用的研究  

Study on the protection of Yufeng Capsule on activity of ATPase in brain tissue of rat with ischemia-reperfusion

作　　者：赵瑛[1] 孙忠人[1] 王薇[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中成药》2002年第8期609-611,共3页Chinese Traditional Patent Medicine

基　　金：黑龙江省自然科学基金资助项目 (课题编号D9816)

摘　　要：目的 :观察御风胶囊 (黄芪 ,丹参 ,天麻等 )对缺血再灌注大鼠脑组织含水量、Na+ ,K+ ATPase和Ca2 + ATPase活性的影响。方法 :采用线栓法造成大鼠脑缺血再灌注模型 ,分别观察脑缺血 2h再灌注 1h及 2 4h脑组织含水量和ATPase活性。结果 :御风胶囊能显著降低缺血再灌注大鼠脑组织含水量 ,保护脑组织Na+ ,K+ ATPase和Ca2 + ATPase活性。结论 :御风胶囊能防治缺血再灌注所致脑水肿 ,其机理可能与其改善脑缺血再灌注后细胞膜离子转运有关。Objective: To observe the effect of Yufeng Capsule (Radix Astragali, Radix Salviae Mitiorrhizae, Rhizoma Gastrodiae, etc) on the moisture content, activity of Na +,K + AT Pase and Ca 2+ ATPase in brain tissue of rat with ischemia reperfusion.Methods:the model with ischemia reperfusion was established by line embolism method, the moisture content and activity of ATPase in brain tissue of model rat were determined respectively at ischemia 2h reperfusion 1h and ischemia 2h reperfusion 24h.Results:Yufeng Capsule could significantly decrease moisture content of rats brain, increase the activity of Na +,K + ATPase and Ca 2+ ATPase.Conclusion:Yufeng Capsule could prevent and treat the cerebral edema caused by ischemia reperfusion, its mechanism may be related to improving cytomembrane ionic transport after ischemia reperfusion.

关 键 词：缺血再灌注 大鼠 脑组织 御风胶囊 脑缺血 脑水肿 ATP酶 

分 类 号：R285.5[医药卫生—中药学] R277.733.1[医药卫生—中医学]