北京地区2003~2013年银杏叶提取物注射液不良反应报告分析  

Analysis on Adverse Drug Reaction Reports Induced by Ginkgo Biloba Leaves Extract Injection from 2003 to 2013 in Beijing

作　　者：朱盛[1] 邢百倩 梅丹[1] 王兰[1] 冯雷[1] 张晓[3] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院药剂科,北京100730 [2]北京市电力医院 [3]北京市药品不良反应监测中心

出　　处：《药物流行病学杂志》2017年第1期50-53,共4页Chinese Journal of Pharmacoepidemiology

基　　金：国家临床重点专科建设项目(编号:国卫办医函[2013]S44号);卫生行业科研专项子项目(编号:200902008-04)

摘　　要：目的:调查北京地区银杏叶提取物注射液(金纳多)所致药品不良反应(ADR)发生情况,为临床合理用药提供参考。方法:对北京地区2003~2013年银杏叶提取物注射液ADR上报信息进行统计归类,对发生人群、ADR症状和累及器官、发生时间、合并用药情况及处理预后情况进行回顾性分析。结果:在114例不良反应报告中,老年患者的构成比大于青壮年患者,女性患者的构成比大于男性,累及皮肤及其附件损害的ADR例数最多(35例),其次为累及神经系统、心血管系统等。ADR发生时间无规律。银杏叶提取物注射液ADR报告中存在9例合并用药现象。新的ADR 8例,无严重ADR。结论:临床应合理使用银杏叶提取物注射液,保证临床用药安全,降低药品不良反应发生风险。Objective： To investigate adverse drug reaction（ ADR） induced by Ginkgo biloba leaves extract injection（ Ginaton injection） in Beijing,and provide reference for clinical application. Methods： The ADRs induced by Ginkgo biloba leaves extract injection from 2003 to 2013 in Beijing were collected and statistically analyzed using retrospective method. Results： In the 114 cases,higher ADR occurrence was observed in elderly patient group than the younger group,and women cover more ADR than men,which accounted to 60. 53%. The clinical manifestation of ADR was mostly the skin and appendix harms,which amount to 30. 70%. Nervous system,circulatory system,etc. were also involved. There were no rules to follow about the occurrence time of ADR induced by Ginkgo biloba leaves extract injection. Adverse reactions happen any time during the delivery. Nine cases were induced by combined use of drugs. There were 8 cases of new ADR. Conclusion： Ginkgo biloba leaves extract injection shoud be used reasonably to ensure the safety of clinical medication,and reduce the incidence of ADR.

关 键 词：银杏叶提取物 药品不良反应 报告 安全用药 

分 类 号：R286[医药卫生—中药学]