芍药甘草汤合四物汤加减结合西医常规疗法治疗糖尿病周围神经病变临床研究  

Clinical study ofShaoyao-Gancao decoction combined withSiwu decoction for the treatment of diabetic peripheral neuropathy

作　　者：刘星[1] 赵荣[1] 张虹[1] 刘瑾琰 

机构地区：[1]辽宁鞍钢集团总医院内分泌科,鞍山114000

出　　处：《国际中医中药杂志》2017年第1期17-21,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的：评价芍药甘草汤合四物汤加减结合西医常规疗法治疗DPN的临床疗效。方法将符合入选标准的76例DPN患者按随机数字表法分为2组，每组38例。对照组在常规治疗基础上配合谷维素注射液治疗，观察组在对照组基础上加用芍药甘草汤合四物汤加减治疗。2组均治疗1个月。分别于治疗前后检测患者FPG、2 hPG、HbAlc、TC、TG、LDL-C、HDL-C水平，采用LBY-N6A自清洗旋转式黏度计检测全血黏度及血浆黏度，采用温氏分血管法检测红细胞压积，采用比浊法检测血小板聚集率，采用肌电仪检测胫神经和腓总神经的神经传导速度（nerve conduction velocity, NCV），评价临床疗效。结果观察组总有效率为89.5%（34/38）、对照组为71.1%（27/38），2组总有效率比较差异有统计学意义（χ2＝4.070，P＝0.044）。治疗后，观察组FPG[（6.12±0.38）mmol/L比（6.58±0.52）mmol/L，t＝4.403]、2 hPBG[（7.83±0.82）mmol/L比（8.41±0.93）mmol/L，t＝2.884]、HbAlc[（6.27±0.52）%比（6.82±0.64）%， t＝4.112]水平低于对照组（P＜0.05）；观察组TC[（4.73±0.83）mmol/L比（5.11±0.64）mmol/L，t＝2.235]、TG[（1.83±0.35）mmol/L 比（2.03±0.41）mmol/L ， t＝2.287]及 LDL-C[（2.91±0.54）mmol/L 比（3.25±0.58）mmol/L，t＝2.645]水平低于对照组（P＜0.05），HDL-C[（1.47±0.33）mmol/L比（1.26±0.31）mmol/L， t＝-2.859]水平高于对照组（P＜0.05）；全血比黏度[（10.16±2.12）mPa？s比（11.33±2.51）mPa？s，t＝2.195]、血浆黏度[（1.24±0.25）mPa？s 比（1.62±0.37）mPa？s ， t＝5.246]、红细胞压积[（0.31±0.16）L/L 比（0.42±0.08）L/L，t＝3.791]及血小板聚集率[（50.21±8.03）%比（54.16±7.82）%，t＝2.172]均低于对照组（P＜0.05）。治疗后，观察组胫神经[（45.22±3.20）m/s 比（38.26±5.19）m/s ， t＝-7.037]与腓总神经[（43.22±6.34）m/s比（36.23±4.81）m/s，t＝-5.415]的NCV高于对照组（P＜0.05）�ObjectiveTo explore clinical effect and safety ofShaoyao-Gancao decoction combined withSiwu decoction for the patients with diabetic peripheral neuropathy （DPN）.MethodsA total of 76 patients with DPN in our hospital from 2013 July to October 2015 were divided into control group and observation group by the random number method, 38 patients in each group. The control group were treated with conventional treatment combined with oryzanol injection, and the observation group were treated with Shaoyao-Gancaodecoction combined withSiwu decoction on the basis of control group. Both groups were treated for one month. The level of FPG, 2 hPG, HbAlc, TC, TG, LDL-C and HDL-C was detected respectively before and after treatment. The whole blood viscosity and plasma viscosity was detected with LBY-N6A self-cleaning＆nbsp;rotary viscosimeter. The red blood cells deposited and platelet aggregation rate were tested with Winchester points vascular method and turbidimetric method, respectively.The leg nerve and sural nerve of nerve conduction velocity （nerve conduction velocity, NCV） were determined with electromyography, at the same time the clinical curative effect was evaluted.ResultsTotal effect rate of observation group was 89.5% （34/38）, which was significantly higher than the control group 71.1% （27/38）, and the difference was statistically significant （χ2=4.070,P=0.044）; After treatment, the levels of FPG （6.12 ± 0.38 mmol/Lvs.6.58 ± 0.52 mmol/L, t=4.403）, 2 hPG （7.83 ± 0.82 mmol/Lvs. 8.41 ± 0.93 mmol/L,t=2.884）, HbAlc （6.27 ± 0.52%vs. 6.82 ± 0.64%, t=4.112） in the observation group were lower than those in the control group （P〈0.05）. The levels of TC （4.73 ± 0.83 mmol/L vs. 5.11 ± 0.64 mmol/L,t=52.235）, TG （1.83 ± 0.35 mmol/Lvs. 2.03 ± 0.41 mmol/L, t=2.287） and LDL-C （2.91 ± 0.54 mmol/Lvs. 3.25 ± 0.58 mmol/L,t=2.645） in the observation group were lower than those in the control group （P〈0.05）, and the HDL-C （1.47 ± 0.33 mmol/Lvs. 1.26 ± 0.31 mmol/L,

关 键 词：糖尿病神经病变 芍药甘草汤 四物汤 谷维素注射液 中西医结合疗法 

分 类 号：R587.2[医药卫生—内分泌]