血必净注射液结合西医常规疗法对慢性阻塞性肺疾病急性加重期患者血管内皮功能及炎症因子的影响  

The effect of Xuebijing injection on vascular endothelial function and inflammatory factor in the patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：李立维[1] 李倩[1] 

机构地区：[1]河北省保定市第一中心医院重症医学科,071000

出　　处：《国际中医中药杂志》2017年第1期26-28,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的：探讨血必净注射液结合西医常规疗法对慢性阻塞性肺疾病急性加重期（acute exacerbations of chronic obstructive pulmonary disease, AECOPD）患者血管内皮功能及炎症因子的影响。方法将符合入选标准的100例AECOPD患者采用随机数字表法分为2组，每组50例。对照组采用西医常规疗法治疗，观察组在对照组基础上静脉滴注血必净注射液。采用ELISA测定血清TNF-a、IL-13、血管内皮生长因子（Serum vascular endothelial growth factor，VEGF）水平，采用硝酸还原酶法测定NO；比较2组患者治疗前后肺活量（forced vital capacity, FVC）、最大呼气峰流速（peak expiratory flow, PEF）、用力呼气容积占用力肺活量之比（FEV1/FVC）。结果治疗后，观察组FVC[（3.23±0.83）L比（2.79±0.71）L， t＝1.786]、PEF[（5.36±0.51）L/s比（4.79±0.46）L/s，t＝1.904]、FEV1/FVC[（59.21±4.38）比（54.94±4.29）， t＝1.882]均高于对照组（P＜0.05）；血清NO[（3.84±0.81）ng/ml比（2.97±0.62）ng/ml，t＝1.869]均高于对照组（P＜0.05）；血清VEGF[（0.14±0.04）ng/ml比（0.17±0.05）ng/ml，t＝2.097]、TNF-a[（0.11±0.03）ng/ml比（0.14±0.02）ng/ml，t＝1.903]、IL-13[（107.27±44.37）ng/ml 比（136.54±48.32）ng/ml，t＝2.005]均低于对照组（P＜0.05）。结论血必净注射液结合西医常规疗法可降低 AECOPD 患者炎症因子水平，改善血管内皮功能和肺功能。Objective To observe the effect ofXuebijing injection on vascular endothelial function and inflammatory factor in the patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods A total of 100 patients with AECOPD were randomly divided into the study and control groups, 50 patients in each group. The control group were given the conventional therapy. The study group were given the Xuebijing injection on the basis of the control group. Both The changes of lung function, vascular endothelial function and inflammatory factor were observed.Results The expression of FVC （3.23 ± 0.83 Lvs. 2.79 ± 0.71 L,t=1.786）, PEF （5.36 ± 0.51 L/svs. 4.79 ± 0.46 L/s,t=1.904）, FEV1/FVC （59.21 ± 4.38vs. 54.94 ± 4.29,t=1.882）, NO （3.84 ± 0.81 ng/mlvs.2.97 ± 0.62 ng/ml,t=1.869） increased significantly in the study group than those in the control group after treatenmt （P〈0.05）. The VEGF （0.14 ± 0.04 ng/ml vs.0.17 ± 0.05 ng/ml, t=2.097）, TNF-a （0.11 ± 0.03 ng/ml vs.0.14 ± 0.02 ng/ml,t=1.903）, IL-13 （107.27 ± 44.37 ng/mlvs. 136.54 ± 48.32 ng/ml,t=2.005） in the study group decreased significantly than those in the control group （P〈0.05）. ConclusionsXuebijing injection could significantly decrease inflammatory factor,and obviously improve vascular endothelial function and lung function,the clinical curative effect is distinct.

关 键 词：肺疾病 慢性阻塞性 血必净注射液 血管内皮功能 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统]