Copper-catalyzed enantioselective cyanation of benzylic C–H bonds via radical relay  

作　　者：Yujie Liang Ning Jiao 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

出　　处：《Science China Chemistry》2017年第1期105-106,共2页中国科学（化学英文版）

摘　　要：Direct methods that enable stereoselective functionalization of C（sp^3）–H bonds could facilitate efficient preparation of therapeutics and agrochemicals,and shall have a major effect on the discovery and development of new pharmaceuticals.Although the transformations through C（sp^2）–H bond cleavage have been significantly developed in the past decades,the direct C（sp^3）–H functionalization,especially the asymmetric transformation is still a big challenge.Direct methods that enable stereoselective functionalization of C(sp^3)–H bonds could facilitate efficient preparation of therapeutics and agrochemicals,and shall have a major effect on the discovery and development of new pharmaceuticals.Although the transformations through C(sp^2)–H bond cleavage have been significantly developed in the past decades,the direct C(sp^3)–H functionalization,especially the asymmetric transformation is still a big challenge.Demon-

关 键 词：Carbon Copper CYANIDES Drug products 

分 类 号：O621.251[理学—有机化学]