CO2激光联合ALA-PDT治疗尿道内尖锐湿疣的可行性及安全性  

Feasibility and safety of CO_2 laser combined with ALA-PDT in treating urethral condyloma

作　　者：姚明珠[1] 曾远娟[1] 赖洪涛[1] 张东兴[1] YAO Ming-zhu ZENG Yuan-juan LAI Hong-tao ZHANG Dong-xing(Department of Skin, People＇s Hospital of Meizhou City in Jiangsu Province,Meizhou 514000,China)

机构地区：[1]江苏省梅州市人民医院风湿皮肤科,江苏梅州514000

出　　处：《中国当代医药》2017年第2期32-34,共3页China Modern Medicine

摘　　要：目的探讨CO_2激光联合ALA-PDT治疗尿道内尖锐湿疣的可行性及安全性。方法随机选择2015年3月~2016年3月我院收治的尿道尖锐湿疣患者112例,将其分为对照组与观察组,各56例,对照组采取CO_2激光疗法,观察组在对照组基础上联合氨基酮戊酸光动力疗法(ALA-PDT)。治疗结束后随访24周,观察疣体复发情况及患者对治疗的满意度。结果治疗后,两组患者第1、2周的一次性治愈率比较,差异无统计学意义(P>0.05);两组患者第4、8、12、24周一次性治愈率比较,差异有统计学意义(P<0.05)。两组患者复发率逐渐增加,到第8周时达到稳定状态;观察组患者复发率明显低于对照组,差异有统计学意义(P<0.05)。观察组患者满意度为96.43%,明显优于对照组的83.93%,差异有统计学意义(P<0.05)。结论采用CO_2联合ALA-PDT治疗尿道内尖锐湿疣能提高一次性治愈率,有效降低复发率,提高患者满意度。Objective To explore the feasibility and safety of CO2 laser combined with ALA-PDT in treating urethral condyloma.Methods 112 urethral condyloma patients from March 2015 to March 2016 in our hospital were randomly selected and were divided into control group and observation group,56 cases in each group.Patients in control group were used CO2 laser,and patients in observation group were used ALA-PDT on the basis of control group.Followed up for 24 weeks after the end of treatment,reeurrene e of warts and patients satisfaction with treatment was observed.Results After treatment,disposable cure rate at one week and two weeks in observation group were compared,the difference had no signifieant（P〉0.05）.The difference of disposable cure rate at 4,8,12 and 24 weeks between two groups had statistical significant （P〈0.05）.The recurrence rate of the two groups increased gradually,and to reach steady state at eighth weeks. Compared between two groups,the recurrence rate of observation group was obvious lower than that of control group, the difference was significant （P〈0.05）.The patients satisfaction in observation group was 96.43%,obvious higher than that was 83.93% in control group,the difference was significant （P〈0.05）.Conclusion Using CO2 laser combined with ALA- PDT in treating urethral eondyloma can improve disposable cure rate,reduce recurrence rate effectively and improve pa- tients satisfaction.

关 键 词：ALA-PDT CO2激光 尿道内尖锐湿疣 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]