玉屏风颗粒联合孟鲁司特治疗儿童咳嗽变异性哮喘临床观察  

Clinical Observation of Yupingfeng Granules Combined with Montelukast for Children with Cough Variant Asthma

作　　者：胡文辉[1] 金丽虹[1] HU Wenhui JIN Lihong

机构地区：[1]浙江省台州医院,浙江台州317000

出　　处：《新中医》2017年第1期124-126,共3页New Chinese Medicine

摘　　要：目的:观察玉屏风颗粒联合孟鲁司特钠咀嚼片治疗儿童咳嗽变异性哮喘(CVA)肺气虚证的临床疗效,及对患儿细胞免疫功能的影响。方法:选取78例CVA肺气虚证患儿为研究对象,随机分为联合组和对照组各39例。对照组予孟鲁司特钠咀嚼片治疗,联合组在对照组用药基础上加用玉屏风颗粒。2组均连续用药3月。治疗后观察2组细胞免疫功能的变化,以及咳嗽症状、肺部体征的改善和复发情况。结果:治疗前,2组CD4^+、CD8^+及CD4^+/CD8+值比较,差异均无统计学意义(P>0.05)。治疗后,2组CD4^+及CD4^+/CD8^+值均较治疗前上升(P<0.05,P<0.01),CD8+均较治疗前下降(P<0.05);联合组CD4^+及CD4^+/CD8^+值均高于对照组(P<0.05),CD8^+低于对照组(P<0.05)。治疗总有效率联合组94.87%,对照组79.49%。2组比较,差异有统计学意义(P<0.05)。结论:玉屏风颗粒联合孟鲁司特钠咀嚼片治疗儿童CVA肺气虚证,临床疗效确切,能有效改善患儿的咳嗽症状和肺部体征,增强细胞免疫功能。Objective：To observe the clinical effect of Yupingfeng granules combined with montelukast sodium chewable tablets in treating children with lung Qi deficiency syndrome of cough variant asthma（CVA） and the effect on cellular immunity of children.Methods：Selected 78 cases of children with CVA as study objects and divided them into the combination group and the control group,39 cases in each group.The treatment of montelukast sodium chewable tablets was given to both groups,and the combination group received additional treatment of Yupingfeng granules.Two groups both received treatment for 3consecutive months.After treatment,observed changes of cellular immunity,the improvement on physical signs of lung and cough as well as the recurrence in both groups.Results：Before treatment,compared CD4^＋,CD8^＋ and CD4^＋/CD8^＋ between two groups,there was no significance in difference（P〉0.05）.After treatment,CD4^＋ and CD4^＋/CD8^＋ in two groups were higher than those before treatment（P〈0.05,P〈0.01）,and CD8^＋ were declined（P〈0.05）.CD4^＋ and CD4^＋/CD8^＋ in the combination group were higher than those in the control group（P〈0.05）,and CD8^＋ in the combination group was lower than that in the control group（P〈0.05）.The total effective rate was 94.87%in the combined group and 79.49%in the control group,the difference being significant（P〈0.05）.Conclusion：The therapy of Yupingfeng granules combination with montelukast sodium chewable tablets for children with lung qi deficiency syndrome of CVA has definite clinical effect.It can effectively improve cough,physical signs of lung and cellular immunity.

关 键 词：咳嗽变异性哮喘(CVA) 肺气虚证 中西医结合疗法 玉屏风颗粒 孟鲁司特钠咀嚼片 细胞免疫 T淋巴细胞亚群 

分 类 号：R256.12[医药卫生—中医内科学]