左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核临床疗效观察  

Clinical efficacy observation of levofloxacin combined with anti-TB chemotherapy in the treatment of smear positive pulmonary tuberculosis

作　　者：罗最容 LUO Zuirong(Department of medicine, The People＇s Hospital of Shaoyang County, Hunan Province, Shaoyang 422100, China)

机构地区：[1]湖南省邵阳县人民医院内三科,422100

出　　处：《临床合理用药杂志》2017年第1期14-15,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察左氧氟沙星联合常规结核化疗方案治疗复治涂阳肺结核患者的临床疗效及安全性。方法将70例复治涂阳肺结核患者随机分为观察组和对照组,每组35例。观察组给予左氧氟沙星联合常规结核化疗方案治疗,对照组给予常规结核化疗方案治疗,比较2组临床治疗效果和不良反应发生率。结果观察组各时间段痰涂转阴率和总有效率均高于对照组,差异均有统计学意义(P<0.05或P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论在抗结核化疗方案的基础上加用左氧氟沙星治疗复治涂阳肺结核患者可显著提高痰涂转阴率,且不增加不良反应,值得临床医师借鉴应用。Objective To observe the clinical efficacy and safety of levofloxacin combined with anti-TB chemotherapy in the treatment of smear positive pulmonary tuberculosis. Methods 70 cases of retreatment smear positive pulmonary tuber- culosis patients were randomly divided into two groups,with 35 cases in each group. Observation group was treated with levo- floxacin combined with conventional anti-TB chemotherapy, and control group was received conventional anti-TB chemotherapy. The clinical efficacy and Incidence of adverse reactions between the two groups were compared. Results The smear-negative rate at each time and the total effective rate in observation group were significantly higher than the control group（ P 〈 0.05 or P 〈 0. 01 ）. The incidence of adverse reactions had no significant difference between the two groups（ P 〉 0.05 ）. Conclusion On the basis of anti-TB chemotherapy plus levofloxacin treatment retreatment smear positive pulmonary tuberculosispatients can significantly increase the rate of sputum smear negative, without increasing adverse effects, clinicians should learn applications.

关 键 词：左氧氟沙星 抗结核化疗方案 复治涂阳肺结核 

分 类 号：R521[医药卫生—内科学]