辛伐他汀对去势骨质疏松症大鼠骨密度和血清降钙素的影响  

The effective of simvastatin on bone mineral density and Bone gla-protein of serum in the ovariectomized female rats

作　　者：杨川[1] 郭涛[1] 吾斯曼江.艾尔肯 冷春涛[1] 

机构地区：[1]新疆医科大学第五附属医院口腔科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2017年第3期345-347,352,共4页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2016C110150)

摘　　要：目的观察辛伐他汀对去卵巢大鼠骨质疏松症骨密度和血清降钙素的影响。方法将63只大鼠随机分为正常对照组、单纯去势组、去势加辛伐他汀治疗组3组,通过手术去除双侧卵巢复制大鼠骨质疏松症模型,各组分别灌胃生理盐水及相应药物12w,检测各组大鼠骨密度及血清降钙素含量。结果与正常对照组比较,单纯去势组、去势加辛伐他汀组骨密度及血清降钙素含量均明显降低,差异有统计学意义(P<0.01);与单纯去势组比较,去势加药组的骨密度及降钙素均明显升高,差异有统计意义(P<0.05)。结论辛伐他汀可能通过升高血清降钙素水平,减缓骨量丢失,起到防治骨质疏松的作用。Objective To study the effect of simvastatin on bone mineral density and Bone gla-protein of se- rum in the ovariectomized female rats. Methods Sixty-three female Wistar rats were randomly divided into three group： control group-A （sham operation group）, ovariectomized group-B（OVX） and OVX with simvastatin treatment as group-C, and established rat model of postmenopausal osteoporosis by removing ovaries. Thirty days after surgery,simvastatin therapy （with simvastatin 5 mg/kg, ig once a day for two weeks, paused for two weeks, and given for anther two weeks, until 12 weeks） in group-C. The rats of other groups were fed with saline. After 12 weeks, Bone mineral density and Bone gla-protein of serum were determined. Results Twelve weeks after administration ,Bone mineral density and Bone gla-protein of serum decreased in ovariectomized group-B （OVX） and OVX with simvastatin treatment group-C compared with those in control group-A （P〈0.01,respectively） ;Bone mineral density and Bone gla-protein of serum increased in OVX with simvastatin treatment group-C compared with those in ovariectomized group-B（OVX） （P〈0.05）. Conclusion Simvastatin can inhabit bone resorption by improving bone gla-protein of serum, and prevent osteoporosis.

关 键 词：辛伐他汀 骨质疏松症 骨密度 血清降钙素 

分 类 号：R56[医药卫生—呼吸系统]