深度水解蛋白配方奶治疗早产儿喂养不耐受的临床观察  

Extensively Hydrolysis Formula Milk Treatment in Premature Infants with Feeding Intolerance

作　　者：何烁[1] He Shuo(Jiangshan Maternal and Child Health Care Hospital, Zhefiang Jiangshan 324100, China)

机构地区：[1]浙江省江山市妇幼保健院,浙江江山324100

出　　处：《儿科药学杂志》2017年第2期18-21,共4页Journal of Pediatric Pharmacy

摘　　要：目的:观察深度水解蛋白配方奶(e HF)治疗早产儿喂养不耐受及生长发育的疗效,与标准早产儿配方奶(SPF)及母乳喂养比较是否存在临床使用价值。方法:选取2014年4月至2015年9月我院收治的发生喂养不耐受且胎龄<34周的早产儿81例,随机分成三组:e HF组29例,予e HF喂养达全胃肠内营养后改SPF喂养;SPF组26例,予SPF喂养至出院;母乳组26例,坚持母乳喂养至出院,其中有9例因无法提供母乳退出该组,实际入组17例。记录患儿临床资料,比较三组之间喂养耐受性、宫外发育迟缓(EUGR)和新生儿坏死性小肠结肠炎(NEC)的发生情况。结果:e HF组与母乳组的胃残留次数、胃残留比比较差异无统计学意义(P>0.05),但较SPF组均明显减少(P<0.05);e HF组与母乳组的肠内营养达基础热卡时间、达全胃肠道营养时间均明显短于SPF组(P<0.05),但e HF组与母乳组比较差异无统计学意义(P>0.05)。e HF组EUGR及NEC发生率与母乳组、SPF组比较差异无统计学意义(P>0.05)。结论:无充足母乳供应时,对喂养不耐受的早产儿予e HF喂养较SPF喂养耐受性更好,能更快达到全胃肠内喂养,且不会增加EUGR及NEC的发生率。Objective： To evaluate the feeding intolerance of extensively hydrolyzed formula（ e HF）,versus standard premature formula（ SPF） and breast milk during feeding premature infants and the clinical effects of growth and development. Methods： Eighty-one premature infants（ gestational age 〈 34 weeks） with feeding intolerance who were admitted to our department from April 2014 to September 2015 were randomized into three groups： e HF group（ n = 29）,SPF group（ n = 26） and breast milk group（ n = 26） groups.The e HF group was fed with e HF and then with SPF after achieving total enteral nutrition. The SPF group was continuously fed with SPF. The breast milk group was fed with breast milk,nine cases quitted because of no breast milk,17 cases were enrolled indeed. The clinical data were recorded,and the feeding tolerance,the incidence of extrauterine growth retardation（ EUGR） and necrotizing enterocolitis（ NEC） were observed. Results： Time to achieve baseline gastrointestinal nutrition and total enteral nutrition were markedly shorter in e HF group than in the SPF group,but there was no difference between breast milk group and e HF group（ P 〉 0. 05）. Both frequency of gastric retention and gastric retention ratio were markedly greater in the SPF group than in the e HF group（ P〈0. 05）,but there was no difference between breast milk group and e HF group（ P 〉 0. 05）. There was no statistical difference in the incidence of EUGR and NEC among three groups. Conclusion： The e HF can reduce feeding intolerance in premature infants and achieve the time to total enteral nutrition,without the increment in the incidence of EUGR and NEC.

关 键 词：深度水解蛋白配方奶 早产儿 喂养不耐受 

分 类 号：R722.6[医药卫生—儿科]