同种和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄有效性的系统评价  

Systematic review of the effectiveness of the same and different drug-eluting stents in the treatment of coronary drug-eluting stent restenosis

作　　者：田云涛[1] 冯伟[1] 胡育英[1] 杨和银[1] 

机构地区：[1]新疆喀什地区第一人民医院心内二科,新疆喀什市844000

出　　处：《中国动脉硬化杂志》2017年第1期71-77,共7页Chinese Journal of Arteriosclerosis

摘　　要：目的评价同种药物洗脱支架和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄的有效性。方法计算机检索Pub Med、OVID、Embase、Cochrane图书馆、万方数据库、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库(VIP),收集同种和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄的临床资料,共纳入10项研究,1680名患者,使用Rev Man5.2软件进行系统评价。检索时间为各大数据库建库至2015年10月。结果在治疗冠状动脉药物洗脱支架内再狭窄时,采用不同药物洗脱支架可降低靶病变血运重建率(OR=0.73,95%CI为0.55~0.96,P=0.02)和主要不良心血管事件发生率(OR=0.72,95%CI为0.54~0.96,P=0.03)。两组间的病死率(OR=1.03,95%CI为0.49~2.16,P=0.95)和心肌梗死发生率(OR=0.59,95%CI为0.24~1.41,P=0.23)无统计学差异。结论对于药物洗脱支架内再狭窄患者,再次植入不同药物洗脱支架比植入同种支架更获益。Aim To investigate the effectiveness of the same and different drug-eluting stent in the treatment of coronary drug-eluting stent restenosis. Methods Pub Med,OVID,Embase,Cochrane Library,Wanfang Database,China Journal Full-text Database（ CNKI）,Chinese Biomedical Literature Database（ CBM）,VIP Database（ VIP） were retrieved. The materials of the treatment in coronary drug-eluting stent restenosis with the same and different drug-eluting stent were collected,10 studies were withdrawed,including 1680 patients. The Rev Man5.2 analysis software was used in systematic review. Control test database computer retrieval to 2015 October. Results The different drug-eluting stent treatment in coronary drug-eluting stent restenosis was found to reduce the odds of target lesion revascularization（ OR =0.73,95%CI was 0.55 ~ 0.96,P = 0.02） and major adverse cardiovascular events（ OR = 0.72,95%CI was 0.54 ~ 0.96,P= 0.03）. There was no difference between the two groups in rates of death（ OR = 1. 03,95% CI was 0. 49 ~ 2. 16,P =0.95） or myocardial infarction（ OR = 0.59,95%CI was 0.24 ~ 1.41,P = 0.23）. Conclusion For patients with restenosis after drug-eluting stent implantation,different drug-eluting stents are more benefit than the same drug-eluting stent implantation.

关 键 词：冠状动脉 再狭窄 药物洗脱支架 

分 类 号：R5[医药卫生—内科学]