组胺与固有免疫调控及其在心血管疾病中的作用  

Histamine,innate immune responses and cardiovascular diseases

作　　者：许莉莉[1] 杨向东[1] 葛均波[1] 

机构地区：[1]复旦大学附属中山医院心内科,上海市200032

出　　处：《中国动脉硬化杂志》2017年第1期83-89,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(81370402;91439121;81230007;81521001);上海市科委基础研究重点项目(13JC1401701)

摘　　要：组胺是人体内重要的参与免疫调节和过敏反应、神经信号传递、胃酸分泌、造血细胞生成等生理病理过程的小分子生物胺。组胺通过作用于细胞表面的组胺受体,激活相应的胞内信号通路,进而发挥一系列生理效应。已有研究表明,炎症与免疫反应贯穿冠心病、心力衰竭、心肌心包炎等心血管疾病的发生发展过程,其中组胺的作用颇受关注。本综述将着眼于探讨组胺对固有免疫反应的调控作用及其对心血管疾病的影响。Histamine is a biogenic amine involved in various pathophysiological processes,such as regulation of immune responses and anaphylactic reaction,neural signal transduction,secretion of gastric acid and hematopoiesis. The effects of histamine is dependent on its binding 4 subtypes of histamine receptors（ HR）,activating different intracellular pathways. Inflammation and immune responses play an important role in multiple cardiovascular disease,including coronary artery diseases,heart failure,myocarditis and pericarditis. The complex regulatory interaction between histamine and immune responses are receiving more and more attention. In this review,we will discuss the effects of histamine in innate immune responses and cardiovascular diseases.

关 键 词：组胺 组胺受体 固有免疫调控 心血管疾病 

分 类 号：R541.4[医药卫生—心血管疾病]