高密度脂蛋白胆固醇水平与高密度脂蛋白功能:孰是孰非?  

The level of high density lipoprotein cholesterol or the function of high density lipoprotein: which one is right?

作　　者：张诗岚 杜晓[1] 刘玲[1] 

机构地区：[1]中南大学湘雅二医院心内科,湖南省长沙市410011

出　　处：《中国动脉硬化杂志》2017年第1期90-94,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81470577;81270956)

摘　　要：早期流行病学研究发现降低的高密度脂蛋白胆固醇(HDLC)水平与增加的冠心病风险密切相关,这促使了高密度脂蛋白抗动脉粥样硬化假说的提出:相对于低密度脂蛋白胆固醇而言,HDLC是"好"的胆固醇,提高血清HDLC水平可能降低心血管事件风险。然而新的研究发现:升高HDLC水平并不能减少临床心血管事件的发生。这使得高密度脂蛋白抗动脉粥样硬化假说遭到质疑。近来,高密度脂蛋白功能而非HDLC水平与动脉粥样硬化的关系被更多地关注。本文就高密度脂蛋白最新相关研究进行综述。Early epidemiological studies have found that lower level of high density lipoprotein cholesterol（ HDLC）is closely associated with an increased risk of coronary heart disease. This prompts a high density lipoprotein anti-atherosclerosis hypothesis： compared to low density lipoprotein cholesterol,HDLC is ＂good＂cholesterol,and increased serum HDLC level may reduce the risk of cardiovascular events. However,new studies have found that elevated HDLC level does not reduce the occurrence of cardiovascular events. This makes the high density lipoprotein anti-atherosclerosis hypothesis be questioned. Recently,the relationship between high density lipoprotein function rather than HDLC level and atherosclerosis has been paid more attention. Latest related research of high density lipoprotein is described in this paper.

关 键 词：高密度脂蛋白 载脂蛋白AⅠ 胆固醇逆向转运 

分 类 号：R5[医药卫生—内科学]