癌症精准医学个体化治疗研究的探索  

Study on Personalized Treatment in Cancer

作　　者：刘谦[1] 王桂茹[2] 高素君[1] 

机构地区：[1]吉林大学第一医院肿瘤中心,中国长春130000 [2]吉林大学第一医院医务部,中国长春130000

出　　处：《国际老年医学杂志》2017年第1期37-41,共5页International Journal of Geriatrics

摘　　要：随着环境污染与变迁，人们生活方式和饮食结构的改变，癌症发病率呈直线上升趋势。预计到2020年全球新发患者可达1500万，死亡1000万，我国与全球同比将上升至300万，死亡220万。为此，人类将面临癌症防治的新挑战。虽然80年代以来癌症防治有所进展，早期治愈率提高卓著。但大部中、晚期治愈水平仍维谷不得攀升。究其原因殊多，然而在临床实践中，由于对“指南”与个体化治疗，在辩证运用上认识不足。所以常出现人为的离轨与偏颇。数千年前，中医“同病异治”的个体化治疗，和现代分子生物学，已告诫我们，个体化治疗是肿瘤防治的核心决策。With deteriorated environmental pollution, changed lifestyle and new diet structure, the incidence of the cancer has been increased dramatically. By 2020, the number of new - onset cancer patients in the world will reach 15 million with a death toll of 10 million, including 3 million new- onset ones and 2. 2 million of death in China. Therefore, cancer prevention and treatment has been the unprecedented challenge faced by the mankind. Some remarkable progresses in cancer control have been made since 1970s, especially the improved cure rates of early stage cancer. However, sometherapy deficiencies still remain in patients with medium or advanced cancer. Although the causes of these deficiencies are varied, lack of personalized treatment is probably the important one. In clinical practice, some doctors use clinical practice guidelines as absolute rules, without a fully understanding of disease differentia- tion or personalized clinical judgment. That makes clinicians lose efficiency in controlling cancer and implementing therapy to individu- al patient. In conclusion, personalized treatment, recommended by evidence - based medicine, transformational molecular biology and traditional Chinese medicine, isthe irreplaceable core strategy of curing cancer.

关 键 词：肿瘤异质性 循证医学 精准医学 中医辨证治疗 分子生物学 

分 类 号：R544.1[医药卫生—心血管疾病]