心源性肝损害对心力衰竭的影响  

Effect of cardiogenic liver injury on heart failure

作　　者：孔繁亮[1] 吴同果[1] KONG Fan-liang WU Tong-guo(Department of Cardiology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guang- zhou 510220, Guangdong, China)

机构地区：[1]暨南大学医学院附属广州红十字会医院、广州市红十字会医院心血管医学部,广东广州510220

出　　处：《心脏杂志》2017年第1期123-126,共4页Chinese Heart Journal

摘　　要：心力衰竭(HF)是当今威胁人类健康的重大临床问题,住院率、死亡率极高。心脏与肝脏之间相互作用的研究较少,相关研究表明HF容易诱发肝功能损害。心源性肝损害临床表现主要包括:腹胀、间断性右上腹不适、恶心、厌食,通常被误认为是胃肠道疾病,往往忽略其对HF的影响。肝功能指标(如TB、GGT、白蛋白)对HF的严重程度及预后均有独立预测价值。而心源性肝损害导致肝脏药代动力学紊乱,使临床用药如履薄冰,应及早重视、干预心源性肝损害,达到个体化治疗,以改善HF症状及预后,降低死亡率。Interaction between heart failure and liver has not been fully demonstrated, although some studies have proven that heart failure can induce liver injury. Cardiogenie liver injury presents abdominal distension, intermittent nosed as gastrointestinal The biomarkers of liver right upper quadrant discomfort, nausea and anorexia, which are often misdiagdisease. The effect of eardiogenic liver injury on heart failure is often neglected. damage （bilirubin, GGT and albumin） can predict the severity and prognosis of heart failure independently. Cardiogenic liver injury influences the hepatic clearance of drugs and early management of eardiogenic liver injury can improve the symptoms and prognosis of heart failure and lower mortality.

关 键 词：心源性肝损害 心力衰竭 肝功能指标 

分 类 号：R541.6[医药卫生—心血管疾病]