联苯菊酯对小鼠肝脏亚急性损伤的研究  

Study on bifenthrin induced subacute liver injury in mice

作　　者：丁爽[1] 张祥[1] 袁从文 林旭[1] 李铁骥[1] DING Shuang ZHANG Xiang YUAN Cong-wen LIN Xu LI Tie-ji(School of Public Health of Jilin University, Changchun 130021 China)

机构地区：[1]吉林大学公共卫生学院,吉林长春130021

出　　处：《工业卫生与职业病》2017年第1期5-7,14,共4页Industrial Health and Occupational Diseases

摘　　要：目的研究联苯菊酯(BIF)对小鼠肝脏的亚急性损伤作用。方法将40只清洁级小鼠随机分为4组:对照组(玉米油)和BIF低、中、高剂量染毒组(7.5、15、30mg/kg),每日灌胃染毒1次,连续染毒28d。测定小鼠血清中总蛋白(TP)、白蛋白(ALB)的浓度,计算球蛋白(GLB)的浓度和白球比(A/G),和肝脏中超氧化物岐化酶(SOD)、过氧化氢酶(CAT)的活力以及丙二醛(MDA)的含量。结果与对照组比较,各剂量染毒组血清TP、ALB和A/G均有所降低,其中低、中、高剂量染毒组ALB差异有统计学意义(P<0.05),中、高剂量染毒组A/G差异有统计学意义(P<0.05)。与对照组比较,各剂量染毒组血清GLB均有所升高,其中中、高剂量染毒组差异有统计学意义(P<0.05)。与对照组比较,各染毒组肝脏SOD、CAT活力均明显降低,其中低、中、高剂量染毒组SOD差异有统计学意义(P<0.05),中、高剂量染毒组CAT差异有统计学意义(P<0.05)。与对照组比较,各染毒组肝脏MDA含量均有所升高,其中中、高剂量组差异有统计学意义(P<0.05)。结论亚急性联苯菊酯染毒可引起小鼠以肝脏合成功能障碍和氧化损伤为主的肝损伤。Objective To explore the effect of BIF on subacute injury of liver in mice.Methods 40 ICR mice were randomly divided into four groups：control group（corn oil）and low,middle and high dose group（7.5,15,30mg/kg）,then were treated through oral administration one time each day for 28 d.The concentrations of serum TP and ALB,GLB and A/G,the vitality of SOD,CAT and MDA content of the liver were determined.Results Compared with the control group,the levels of serum TP,ALB and A/G in each dose group were decreased.There was statistically significant difference of the ALB in the middle and the high dose exposure groups（P〈0.05）,and of the A/G in the high dose exposure group（P〈0.05）.Compared with the control group,the serum levels of GLB in each dose group were increased,and the difference was statistically significant（P〈0.05）in the middle and the high dose groups.Compared with the control group,the liver SOD and CAT activity of the exposed group were significantly decreased.Statistically significant difference of the SOD was found in the middle and high dose exposures（P〈0.05）,and of CAT in the high dose exposure group（P〈0.05）.Compared with the control group,the levels of MDA in liver of each group were increased,and there was significant difference between the middle and the high dose group（P〈0.05）.Conclusions Subacute bifenthrin exposure may cause liver synthesis dysfunction and oxidative damage in mice.

关 键 词：联苯菊酯 亚急性 小鼠 肝损伤 

分 类 号：R994.6[医药卫生—毒理学]