PET/CT下合并肺不张非小细胞肺癌的治疗结果和预后分析  

Prognosis of Non-small Cell Lung Cancer Complicated with Atelectasis Based on PET/CT

作　　者：宋颖秋[1,2,3] 王天禄[1,2,3] 党军[1] 李亚明[1] 李光[1] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001 [2]辽宁省肿瘤医院,辽宁沈阳110042 [3]中国医科大学肿瘤医院,辽宁沈阳110042

出　　处：《中国肿瘤》2017年第1期68-72,共5页China Cancer

基　　金：辽宁省科学技术计划项目(2013225021);沈阳市科学技术项目(F11-264-1-41)

摘　　要：[目的]分析在PET/CT指导下合并肺不张的非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗结果及预后因素。[方法 ]对36例PET/CT定位扫描伴有不同程度肺不张的NSCLC患者的治疗结果进行分析,采用Kaplan-Meier法计算其生存率,Log-rank法检验和单因素预后分析,采用Cox模型多因素预后分析。[结果]1、2、3、5年生存率分别为61.1%、27.8%、13.9%和8.3%,中位生存期14个月;1、2、3、5年无进展生存率分别为36.1%、16.7%、8.3%和8.3%,中位无进展生存期10个月。单因素分析结果显示影响NSCLC合并肺不张预后因素有临床分期、是否复张、肺不张范围、治疗前血红蛋白含量。COX多因素分析显示,是否复张是合并肺不张NSCLC患者独立预后因素(χ2=7.88,P=0.043)。[结论 ]PET/CT指导下治疗合并肺不张NSCLC有生存获益趋势,是否复张是影响其生存的独立预后因素,值得临床大样本前瞻性研究进一步探讨。[Purpose] To investigate prognostic factors in non-small cell lung cancer（NSCLC） patients complicated with atelectasis based on PET/CT. [Methods] The survival data of 36 NSCLC cases pathologically proven complicated with atelectasis with PET/CT scanning were analyzed prospectively. The factors related to survival was evaluated by univariate and multivariate analyses.[Results] The overall 1-,2-,3- and 5-year survival rate was 61.1%,27.8%,13.9% and 8.3% respectively,with a median survival time of 17 months. The 1-,2-,3- and 5-year progression free survival（PFS） rate was 36.1%,16.7%,8.3% and 8.3% respectively,with a median PFS of 10 months. Univariate analysis showed that clinical stage,re-expansion of atelectasis,the range of atelectasis,and hemoglobin were significant factors affecting survival. Multivariate analysis showed that resolution of atelectasis was the the only significant factor affecting survival（χ2=7.88,P=0.043）.[Conclusion] Re-expansion of the atelectasis is a predicting factor for a favorable outcome of NSCLC patients.

关 键 词：PET/CT 放疗 非小细胞肺癌 肺不张 预后 

分 类 号：R734.2[医药卫生—肿瘤]