快速膜乳化法制备齐墩果酸微粒的工艺研究  

Preparation of Oleanolic Acid Particles through Premix Membrane Emulsification

作　　者：吴晨悦 范文硕[1] 田娟[1] 蔡程科[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中医药信息》2017年第1期29-33,共5页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(No.81173562);北京中医药大学自主选题在读研究生项目(No.2016-JYB-XS102)

摘　　要：目的:初步建立无包载辅料的齐墩果酸微粒的制备方法,对制备工艺进行考察和优化,得到分散性好、粒径均一、分布窄的齐墩果酸微粒。方法:以齐墩果酸微粒的平均粒径Z-average、多分散指数PDI为主要指标,辅以电镜观察,对影响齐墩果酸微粒成型和分散性的各因素进行考察。结果:制备的齐墩果酸微粒冻干粉平均粒径(434.7±39.06)nm,PDI(0.25±0.08),大小均匀,分散性好。结论:不锈钢快速膜乳化法可用于中药难溶性成分齐墩果酸的微粒制备,具有良好的开发前景。Objective： To achieve well dispersible, relatively uniform and narrow size distribution Oleanolic Acid （OA） particles without coating materials and to establish a method and optimize the process parameters. Methods ： Take Z - average and PDI of OA particles as main indexes, and supplement electron microscope to investigate the factors which may influence the shape and dispersibility of OA particles. Results： Uniform and well dispersible OA particles were prepared by premix membrane emulsification method. The average particle size was （434.7 ±39.06）nm and PDI was （0.25 ±0.08）. Conclusion： Stainless steel premix membrane emulsification could be used to prepare insoluble component OA particles, and has a promising developmental prospect.

关 键 词：齐墩果酸 快速膜乳化法 微粒 

分 类 号：R283.6[医药卫生—中药学]