血清β2-微球蛋白与系统性红斑狼疮疾病活动度及其肾脏损害的相关性  

Relationship between serum levels of β2-microglobulin and disease activity together with renal damage in systemic lupus erythematosus patients

作　　者：徐萍[1] 周蕾[1] 

机构地区：[1]天津医科大学总医院风湿免疫科,天津300052

出　　处：《天津医科大学学报》2017年第1期41-43,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨系统性红斑狼疮(SLE)患者血清β2-微球蛋白水平与疾病活动度及其肾脏损害的相关性及临床意义。方法:采用放射免疫法测定107例SLE患者血清β2-微球蛋白水平,观察其与病情活动指标及肾脏损害的相关性。结果:SLE疾病活动期患者血清β2-微球蛋白水平显著高于缓解期患者[(4.76±3.00)mg/L vs(2.45±1.17)mg/L],狼疮肾炎组患者血清β2-微球蛋白水平显著高于非狼疮肾炎组[(3.92±2.85)mg/L vs(2.63±1.25)mg/L],分别比较差异具有统计学意义(P<0.05);血清β2-微球蛋白水平与SLE疾病活动性指数(SLEDAI)、24 h尿蛋白呈正相关(分别为r=0.632,r=0.229,P<0.05)。结论:血清β2-微球蛋白与系统性红斑狼疮疾病活动及其肾脏损害相关。Abstract Objective： To explore the clinical significance of serum levels of β2-microglobulin and disease activity together with renal damage in systemic lupus erythematosus （SLE）patients. Methods： The levels of serum β2-microglobulin were measured by radioimmunoassay in 107 patients with SLE. Results： The levels of serum β2-microglobulin were significantly higher in active group than remisson group [（4.76±3.00） mg/L vs （2.45±1.17） mg/L], the concentrations of serum β2-microglobulin in lupus nephritis patients were significantly higher than non-lupus nephritis group [（3.94±3.07） mg/L vs （2.86±1.47） mg/L]. The levels of serum β2-microglobulin were positively correlated with SLE disease activity index （SLEDAI）and 24 hours urine protein （respectively, r=0.632,r=0.225, P〈0.05）. Conclusion： Serum β2-microglo bulin may associate with disease activity and renal damage in patients with SLE.

关 键 词：红斑狼疮 系统性 Β2-微球蛋白 疾病活动度 肾脏损害 

分 类 号：R593.241[医药卫生—内科学]