大鼠口服五氯柳胺的急性毒性研究  

Study on the acute toxicity of oxyclozanide in rats by oral administration

作　　者：张吉丽[1] 张继瑜[1] 朱阵 程富胜[1] 周绪正[1] 李冰[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室,兰州730050

出　　处：《黑龙江畜牧兽医》2017年第2期185-186,共2页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家现代农业产业技术体系专项(CAR-38);"十二五"国家科技支撑计划项目(2015BAD1101)

摘　　要：为了研究口服五氯柳胺对大鼠的急性毒性,试验对SD大鼠灌胃给药,观察7 d,记录死亡数,并用简化寇氏法计算半数致死量(LD_(50))及95%的可信限。结果表明:五氯柳胺对大鼠的急性毒性LD_(50)为3.707 g/kg,95%的可信限范围为3.148~4.365 g/kg。说明五氯柳胺为低毒物质。To study the acute toxicity of oral administration of oxyclozanide in rats, the SD rats were orally and intragastrically administrated. The rats were observed for 7 d, and the number of deaths was reeorded, while the simplified Karber＇ s method was used to calculate the median lethal dose （ LD50 ） and 95% confidence limits. The results showed the acute toxicity LD50 of oxyclozanide in rats was 3. 707 g,/kg, and the 95% confidence limits ranged from 3. 148 to 4. 365 g/kg. The results indicate that oxyclozanide is a low - toxic substance.

关 键 词：五氯柳胺 大鼠 急性毒性 半数致死量(LD50) 95%的可信限 低毒 

分 类 号：S865.1[农业科学—野生动物驯养]