甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究  

Clinical trial of insulin glargine combined with acarbose on type 2 diabetes with secondary failure

作　　者：杨华[1] 许学忠[2] 祁平[2] 吴海清[2] 张艳[2] 

机构地区：[1]万宁市人民医院门诊部,海南万宁571500 [2]万宁市人民医院内分泌科,海南万宁571500

出　　处：《中国临床药理学杂志》2017年第3期219-221,共3页The Chinese Journal of Clinical Pharmacology

基　　金：海南省卫计委基层适宜技术推广基金资助项目[琼卫科教2015(74)号]

摘　　要：目的观察甘精胰岛素注射液联合阿卡波糖片治疗磺脲类继发性失效的2型糖尿病患者的临床疗效。方法 80例磺脲类继发性失效的2型糖尿病患者均皮下注射甘精胰岛素注射液,每次10单位,每天1次;口服阿卡波糖片,每次50 mg,每天3次。治疗期间根据患者血糖变化对甘精胰岛素及阿卡波糖用量进行调整,疗程为3个月。观察治疗前后患者的临床疗效、血糖控制情况及药物不良反应发生情况。结果治疗后,临床总有效率为90.00%(72/80例)。治疗前,患者空腹血糖、餐后血糖、糖化血红蛋白(Hb A1c)含量分别为(9.34±2.04)mmol·L^(-1),(12.15±3.61)mmol·L^(-1),(8.82±2.53)%,治疗后,患者空腹血糖、餐后血糖、糖化血红蛋白含量分别为(6.23±1.26)mmol·L^(-1),(8.35±2.18)mmol·L^(-1),(6.64±1.23)%,差异有统计学意义(P<0.05)。治疗过程中,头晕、心慌、出冷汗、视物模糊等药物不良反应发生率为8.75%(7/80例),对症治疗后消失。结论甘精胰岛素注射液联合阿卡波糖片治疗继发性失效的2型糖尿病患者,有效控制血糖水平,药物不良反应发生率低。Objective To investigate the clinical efficacy of insulin glargine combined with acarbose on type 2 diabetes with secondary failure. Methods Eighty cases of type 2 diabetes with secondary failure were selected and treated with insulin glargine 10 U every time,qd;acarbose 50 mg,tid. The dose was adjusted according to the changes of the blood glucose. All patients were treated for 3 months. Clinical efficacy,blood glucose and incidence of adverse drug reactions were observed.Results After treatment,the clinical effective rate was 90. 00%（ 72 /80cases）. The levels of fasting blood glucose,postprandial blood glucose,and glycosylated hemoglobin（ Hb A1c） were（ 6. 23 ± 1. 26） mmol·L^-1,（ 8. 35 ±2. 18） mmol·L^-1,（ 6. 64 ± 1. 23） % after treatment,significantly lower than those before treatment,which were（ 9. 34 ± 2. 04） mmol·L^-1,（ 12. 15 ± 3. 61） mmol·L^-1,（ 8. 82 ± 2. 53） %. The incidence of adverse reactions such as dizziness,palpitation,sweating,blurred vision was 8. 75%（ 7/80 cases）, which disappeared after symptomatic treatment.Conclusion Insulin glargine combine with acarbose was effective in the treatment of diabetic patients with secondary failure,which can effectively controll blood glucose level,with low incidence of adverse drug reactions.

关 键 词：继发性失效 糖尿病 甘精胰岛素 阿卡波糖 

分 类 号：R977.15[医药卫生—药品]