错配修复系统在肿瘤形成中的作用研究进展  

Progress in mismatch repair system in tumor formation

作　　者：靳振岭 赵丹 丁铭 

机构地区：[1]陕西省第四人民医院重症医学科,西安710043

出　　处：《中国临床药理学杂志》2017年第3期284-288,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：DNA修复的缺陷对肿瘤的形成具有重要意义。位于基因组上的微卫星序列是DNA复制过程中最容易发生错配的序列,需要错配修复基因(mismatch repair gene,MMR)通过错配修复机制进行修复。如果MMR发生突变,造成功能丧失,将会导致肿瘤的发生。本文通过对先前DNA错配修复系统及其在各系统肿瘤中的作用作一总结,以便对肿瘤形成的分子水平研究及治疗提供依据。Defects in DNA repair play an important role in tumor formation. Microsatellites located in the genome are the most prone to mismatches in the DNA replication process. Mismatch repair gene（ MMR） is required to repair the mismatch repair mechanism. If the MMR mutation results in loss of function,it will lead to tumorigenesis. In this paper,the previous DNA mismatch repair system and its role in the tumor in each system will be summarized,hoping to provide the basis for the future research of tumor formation in the molecular level and its treatment.

关 键 词：DNA错配修复 微卫星 错配修复基因 微卫星不稳定性 肿瘤 

分 类 号：R979.1[医药卫生—药品]