大米草黄酮对小鼠H22肝癌细胞及移植瘤作用  

The Effect of the Flavonoids from Spartina anglica on H22 Hepatoma Cells and Cancer Xenograft

作　　者：罗彩林[1] 邱丹缨 郑智华[1] 温扬敏[1] 

机构地区：[1]泉州医学高等专科学校基础医学部,福建泉州362000

出　　处：《泉州师范学院学报》2016年第6期27-30,共4页Journal of Quanzhou Normal University

基　　金：福建省教育厅科技项目(JA14394);泉州市科技重点项目(2014Z59);骨干院校建设科研项目(XJ1307)

摘　　要：采用CCK-8法检测大米草黄酮对H22肝癌细胞增殖活力的影响,建立小鼠H22肝癌移植瘤模型,观察大米草黄酮对小鼠体内移植瘤生长的影响.结果表明:大米草黄酮能抑制体外培养的小鼠H22肝癌细胞的增殖活力,并能抑制小鼠体内H22肝癌移植瘤的生长,其中大米草黄酮高浓度组(60mg/mL)的抑瘤率达到57.07%.Effect of the flavonoids from Spartina anglica on proliferation of H22 cells was determined by CCK-8assay.To investigate antitumor effect of flavonoids fromSpartina anglica on cancer xenograft in mice,the H22 transplanted mouse models were established.The flavonoids from Spartinaanglica could inhibit the growth of H22 hepatoma cells cultivated in vitro,and had an antitumor effect on H22 transplanted tumor in mice.As flavonoids fromSpartina anglica concentration was 60mg/mL,inhibitory rate reached 57.07%.

关 键 词：大米草黄酮 肝癌 抗肿瘤 

分 类 号：Q94-33[生物学—植物学] R285.5[医药卫生—中药学]