阳离子抗菌肽溶血性的研究进展  

The Research Progress of Cationic Antimicrobial Peptides on Hemolysis

作　　者：李绘春[1] 荣炜炜 钱康英 陈玉清[1] LI Hui-chun RONG Wei-wei QIAN Kang-ying CHEN Yu-qing(Jiangsu Provincial Key Laboratory of Molecular and Medical Biotechnology, Life Sciences School, Nanjing Normal University, Nanjing 210000, China)

机构地区：[1]南京师范大学生命科学学院江苏省分子医学生物技术重点实验室,江苏南京210000

出　　处：《药物生物技术》2016年第6期535-539,共5页Pharmaceutical Biotechnology

基　　金：国家自然科学基金资助项目(No.81573337;No.30900743);江苏省自然科学基金资助项目(No.BK20141446)

摘　　要：阳离子抗菌肽是一类小分子多肽,具有抗细菌、抗真菌、病毒等微生物感染以及杀伤恶性肿瘤细胞等多种生物学功能,具有发展为新型抗菌、抗癌药物的重要应用前景。然而,抗菌肽的溶血毒性仍然是阻碍抗菌肽应用的关键因素。该文主要从螺旋度、两亲性、疏水性、电荷等阳离子抗菌肽自身的结构参数以及膜脂、膜蛋白、糖分子等红细胞膜的结构组分两方面对抗菌肽溶血机制的研究进展进行了综述,并简述了降低溶血性的研究进展,期望能有助于设计治疗潜力的抗菌肽应用于临床。Cationic antibacterial peptides,which were small molecule polypeptides,have been shown to have antibacterial, antifungal, antivirus and anticancer activities. Therefore, they have gained much attention as potential antimicrobial and anticancer agents in the future. However,the hemolysis is a problem which has hampered its application. The current research progress is about mechanism of hemolysis from two aspects ： the structural parameters of antimicrobial peptides, including helicity, amphipathicity, hydrophobicity and net charge; and the composition of erythrocyte membrane,including the membrane lipids, membrane proteins and carbohydrates, are mainly summarized. The progress of reducing the hemolysis is also discussed, expecting to guide the design of therapeutic potential of antimicrobial peptides used in clinical.

关 键 词：阳离子抗菌肽 溶血性 结构参数 红细胞 细胞膜 

分 类 号：Q514.3[生物学—生物化学] R963[医药卫生—微生物与生化药学]