注射用脂溶性维生素（Ⅱ）致患儿药物热和皮疹  

Fever and rash due to fat-soluble vitamins （ Ⅱ ） in a child

作　　者：田巧焕 陈丽芳 吝战权[2] 朱建新[2] 赵继红[2] 马丽萍[2] 

机构地区：[1]山东省聊城市第三人民医院儿科,252000 [2]北京大学首钢医院药剂科临床药学室,100144

出　　处：《药物不良反应杂志》2016年第6期473-474,共2页Adverse Drug Reactions Journal

摘　　要：1例9岁女性患儿畸胎瘤切除术后给予头孢呋辛1.5 g静脉滴注、1次/12 h，注射用脂溶性维生素（Ⅱ）1支、1次/d和注射用水溶性维生素10 ml、1次/d。首次输注脂溶性维生素液和水溶性维生素时出现轻度胸闷和烦躁；每次输注后1～3 h，患儿体温明显升高。第4天，患儿颜面部、耳后、躯干部出现红色点片状斑丘疹，逐渐发展至四肢和手足。停用注射用脂溶性维生素（Ⅱ），注射用水溶性维生素继续应用。12 h后，患儿体温恢复正常，皮疹减少。次日皮疹消失。A 9-year-old girl received intravenous infusions of cefuroxime 1.5 g twice daily, fat-soluble vitamins （Ⅱ） 1 bottle once daily and water-soluble vitamin 10 ml once daily after resection of teratoma. Mild chest tightness and irritability appeared after the first infusion of fat-soluble vitamin and water-soluble vitamin. One to three hours after each infusion, her body temperature significantly increased. On day 4, erythematous spotted and patchy maculopapular rashes occurred on her face, ear, trunk, and gradually extended developed to the limbs, hand and foot. Fat-soluble vitamins （Ⅱ） was stopped, and water-soluble vitamins were continued to use. The patient′ body temperature returned to normal and the rash gradually reduced after 12 hours. On the following day, the rash disappeared.

关 键 词：用药错误 发热 药疹 脂溶性维生素(Ⅱ) 

分 类 号：R977.2[医药卫生—药品]