低分子肝素治疗新生儿脓毒症并DIC的临床研究  

Clinical Research of Low Molecular Heparin in Treatment of Neonatal Sepsis Complicated with DIC

作　　者：张升荣[1] 李晓东[1] 田青[1] 蔡琳[1] ZHANG Sheng-rong LI Xiao-dong TIAN Qing CAI Lin(The Department of Neonatal, Nanshan People＇s Hospital Affiliated to Guangdong Medical College, Shenzhen518052)

机构地区：[1]广东医学院附属南山人民医院新生儿科,深圳518052

出　　处：《实用中西医结合临床》2016年第9期14-16,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的：为患有脓毒症合并DIC的新生儿使用低分子肝素治疗,研究其疗效。方法：按照入院单双数将74例于2013年4月~2016年6月入诊我院儿科的脓毒症合并DIC的新生儿分为A、B组各37例,其中A组使用普通肝素进行治疗,B组采用低分子肝素治疗,对比两组患者治疗疗效、临床症状改善时间以及DIC指标变化情况。结果：B组总有效率为94.59%,高于A组的78.38%,P〈0.05。B组患儿肝素使用时间、出血停止时间以及DIC指标恢复正常时间均短于A组,P〈0.05。治疗前两组患儿DIC指标水平比较无明显差异,P〉0.05;治疗后B组患儿APTT、PT、D-D、FDP、Fbg以及PLT水平均明显优于A组,P〈0.05。结论：对新生儿脓毒症并DIC患儿使用低分子肝素疗效更佳,且临床症状改善时间和肝素使用时间更短,DIC指标恢复情况较好,值得临床应用及推广。Objective： To study the c linical effect of low molecular heparin in treatment of neonatal sepsis complicated with DIC（disseminated intravascular coagulation）. Method： 74 Neonatal sepsis complicated with DIC treated from April 2013 to June 2016 in our department were divided into two groups. The group A took heparin; the group B took the low molecular heparin. The clinical effect, time of improving the clinical symptoms and DIC index for two groups were compared. Result： The total effective rate of the group B（94.59%）was higher than that of the group A（78.38%）（P〈0.05）; the usage time, time of stopping bleeding and recovery time of DIC index of the group B were shorter than that of the group A（P〈0.05）; before treatment, the DIC index of two groups had no significant different（P〈0.05）, after treatment, the index of APTT, PT, D-D, FDP, Fbg and PLT of the group B were better than that of the group A（P〈0.05）.Conclusion： The low molecular heparin has better effect in treatment of neonatal sepsis complicated with DIC, can shorten the time of improving the clinical symptoms and usage time of heparin, and promote DIC index. It is worthy of clinical application and promotion.

关 键 词：脓毒症 新生儿 弥散性血管内凝血 低分子肝素 临床研究 

分 类 号：R722.1[医药卫生—儿科]