探讨重组人脑利钠肽对行急诊冠状动脉介入治疗的前壁心肌梗死患者左室功能的影响  

Investigation of influence by recombinant human brain natriuretic peptide on left ventricular function in anterior myocardial infarction patients during emergency coronary intervention

作　　者：肖丽[1] 智永超[1] 

机构地区：[1]大连市中心医院心内科,116013

出　　处：《中国实用医药》2016年第35期122-124,共3页China Practical Medicine

摘　　要：目的探讨前壁心肌梗死患者实施急诊冠状动脉介入治疗中重组人脑利钠肽对其左室功能的影响。方法 72例实施急诊冠状动脉介入治疗的前壁心肌梗死患者随机分为研究组(36例,采用重组人脑利钠肽治疗)与对照组(36例,采用常规药物治疗),对比两组治疗效果。结果治疗后,研究组左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心房内径(LAD)分别为(50.4±15.4)%、(45.2±12.0)mm、(35.1±9.2)mm,对照组分别为(42.3±12.5)%、(53.6±14.3)mm、(37.5±9.5)mm,两组LVEF、LVEDD比较,差异具有统计学意义(P<0.05),但两组LAD比较,差异无统计学意义(P>0.05)。治疗后,研究组白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、可溶性细胞间黏附分子-1(s ICAM-1)、可溶性血管细胞黏附分子-1(s VCAM-1)分别为(24.1±4.1)ng/L、(6.8±3.1)mg/L、(22.5±3.1)ng/ml、(22.6±3.6)ng/L,对照组分别为(32.4±2.5)ng/L、(10.5±3.2)mg/L、(31.8±2.6)ng/ml、(32.9±2.5)ng/L,两组上述指标比较,差异具有统计学意义(P<0.05)。研究组1例急性左心衰竭,不良心脏事件发生率为2.8%;对照组发生3例急性左心衰竭,2例梗死后心绞痛,1例原位再梗死,不良心脏事件发生率为16.7%;两组不良心脏事件发生率比较,差异具有统计学意义(P<0.05)。结论在前壁心肌梗死患者实施急诊冠状动脉介入治疗过程中,实施重组人脑利钠肽治疗的效果显著,能对患者左室功能进行改善,值得推广应用。Objective To investigate by recombinant human brain natriuretic peptide on left ventricular function in anterior myocardial infarction patients during emergency coronary intervention. Methods A total of 72 patients with anterior myocardial infarction during emergency coronary intervention were randomly divided into research group（36 cases, received recombinant human brain natriuretic peptide for treatment） and control group（36 cases, received conventional drug therapy）. Curative effects were compared between the two groups. Results After treatment, the research group had left ventricular ejection fraction（LVEF）, left ventricular end diastolic dimension（LVEDD） and left atrial dimension（LAD） respectively as（50.4±15.4）%,（45.2±12.0） mm and（35.1±9.2） mm, which were respectively（42.3±12.5）%,（53.6±14.3） mm and（37.5±9.5） mm in thecontrol group. The difference of LVEF and LVEDD had statistical significance between the two groups（P〈0.05）, while there was no statistically significant difference of LAD between the two groups（P〉0.05）. After treatment, the research group had interleukin-6（IL-6）, high-sensitivity C-reactive protein（hs-CRP）, soluble intercellular adhesion molecule-1（s ICAM-1）, and soluble vascular cell adhesion molecule-1（s VCAM-1） respectively as（24.1±4.1） ng/L,（6.8±3.1） mg/L,（22.5±3.1） ng/ml and（22.6±3.6） ng/L, which were respectively（32.4±2.5） ng/L,（10.5±3.2） mg/L,（31.8±2.6） ng/ml and（32.9±2.5） ng/L in the control group. The difference of indexes had statistical significance between the two groups（P〈0.05）. There was 1 case with acute left heart failure in the research group, with incidence of adverse cardiac events as 2.8%. There were 3 cases with acute left heart failure in the control group, 2 cases with post-infarction angina pectoris, and 1 case with re-infarction, with incidence of adverse cardiac events as 16.7%. The difference of incidence of adverse cardiac events had statistical

关 键 词：前壁心肌梗死 急诊冠状动脉介入 重组人脑利钠肽 左室功能 

分 类 号：R542.22[医药卫生—心血管疾病]