甲巯咪唑所致的白细胞减少症与HLA-DRB1* 08032基因关联性个案分析  

Analysis of HLA-DRB1* 08032 Gene in Drug-Induced Thiamazole Caused by Leukopenia

作　　者：廖伟坚[1] 李泳宁[1] 黄剑清 

机构地区：[1]福建卫生职业技术学院,福州350101 [2]福州市皮肤病防治院,福州350025

出　　处：《海峡药学》2016年第12期278-280,共3页Strait Pharmaceutical Journal

基　　金：2014年福州市科技项目(编号:2014-G-59)

摘　　要：目的探讨甲巯咪唑所致的白细胞减少症与HLA-DRB1*08032基因的关系。方法对甲巯咪唑所致的白细胞减少症患者血液进行HLA-DRB1*08032基因的检测。结果测序结果与IMGT/HLA数据库进行比对,与HLA-DRB1*08032基因序列完全一致。结论通过研究表明本例甲巯咪唑所致的白细胞减少症患者具有HLA-DRB1*08032基因。OBJECTIVE To study the relationship between Thiamazole caused by Leukopenia and HLADRB1＊08032 Gene. METHODS HLA-DRB1＊08032 Gene detection of Thiamazole-induced Leukopenia effected patient＇s blood sample. RESULTS Comparing the result to IMGT / HLA database,the result is in full accord with the HLA-DRB1＊08032 gene sequence. CONCLUSION The study shows that the patient with Thiamazole-induced Leukopenia carries the HLA-DRB1＊08032 gene.

关 键 词：甲巯咪唑 白细胞减少症 HLA-DRB1＊08032基因 

分 类 号：R968[医药卫生—药理学]