截瘫三联针联合康复训练对脊髓损伤患者CGRP水平、运动功能及日常生活能力的影响  

Effect of Triple Acupuncture Therapy Combined with Rehabilitation Training on CGRP Content in Peripheral Blood,Motor Function and Activity of Daily Living of Spinal Cord Injury Patients

作　　者：崔银洁[1] 王倩[2] 江玥[2] 张安仁[2] CUI Yinjie WANG Qian JIANG Yue ZHANG Anren(College of Acupuncture and Moxibustion, Tianjin University of Traditional Chinese Medicine, Tianjin 300172, China Chengdu Military General Hospital, People ＂s Liberation Army of China, Che ngdu, Siehuan 610083, China)

机构地区：[1]天津中医药大学针灸推拿学院,天津300172 [2]中国人民解放军成都军区总医院,四川成都610083

出　　处：《康复学报》2016年第2期6-11,共6页Rehabilitation Medicine

基　　金：军队中医药科研专项重点项目(10ZYZ118)

摘　　要：目的:观察截瘫三联针法联合康复训练对脊髓损伤(SCI)患者外周血降钙素基因肽(CGRP)的影响。方法:50例患者按照随机数字表随机分为治疗组与对照组,每组25例。2组均采用基础康复训练法,治疗组加用截瘫三联针法,对照组加用常规体针法。每日1次,1个月为1个疗程,共治疗3个疗程。另选健康体检者25例作为正常空白组。于治疗前、治疗1个月、2个月、3个月后检测2组患者外周血CGRP含量,同时进行ASIA运动、ASIA感觉(轻触觉、针刺觉)、改良Barthel指数评定。结果:治疗前2组CGRP含量低于正常空白组,差异具有统计学意义(P<0.05);治疗1个月后治疗组CGRP含量高于对照组,差异有统计学意义(P<0.05);治疗3个月后2组运动功能、轻触觉、针刺觉评分较治疗前有明显提高(P<0.05),治疗2个月、3个月后2组改良Barthel评分较治疗前明显提高,但2组组间比较无显著差异;相关分析提示CGRP与针刺觉、轻触觉、运动评分具有相关性(P<0.05)。结论:截瘫三联针法联合康复训练对SCI患者早期CGRP影响较大;CGRP与运动、感觉、改良Barthel指数评分相关,提示早期综合治疗对SCI患者功能改善有重要作用;脊髓损伤后早期外周血检测CGRP可预测SCI患者功能恢复潜力。Objective：To observe the effect of triple acupuncture therapy combined with rehabilitation training on calcitonin gene-related peptide（CGRP） content in peripheral blood of spinal cord injury（SCI） patients. Methods：50 SCI patients meeting study criteria were randomly assigned to treatment group（n=25） and control group（n=25）. Both groups received rehabilitation training,the treatment group was added with triple acupuncture therapy,and the control group was added with regular meridians acupuncture therapy for one time per day and one month as a course. All patients received three courses of treatment. 25 healthy subjects were enrolled as normal control group. Before treatment,after one month,two months,and three months of treatment,CGRP content in peripheral blood of the two groups was detected,and the American spinal injury association（ASIA） motor score,ASIA sensory score,modified Barthel index（MBI） score were measured. Results：The CGRP content in the two groups was lower significantly than that in the normal control group（P〈0.05）. After one month of treatment,the CGRP content in treatment group was higher significantly than that in the control group（P〈0.05）. After three months of treatment,the ASIA motion score and ASIA feel score were significantly increased in the treatment and control groups（P〈0.05）. After two months,three months of treatment,MBI scale in the two groups was significantly increased,but there was not significant difference between the two groups（P〉0.05）. The CGRP content was correlated with ASIA motor score,ASIA sensory score and MBI score（P〈0.05）. Conclusion：Triple acupuncture therapy combined with rehabilitation training has an important effect on CGRP content in peripheral blood,ASIA motor score,ASIA sensory score and MBI score of SCI patients in the early phase of treatment,which suggests an important role of early comprehensive treatment on function remodeling of SCI patients. The CGRP content in peripheral blood may be a potentia

关 键 词：脊髓损伤 康复训练 截瘫三联针法 降钙素基因肽 

分 类 号：R246.2[医药卫生—针灸推拿学]