卵巢过度刺激综合征高风险患者行全胚冷冻的临床应用价值研究  

Clinical application of frozen-thawed blastocyst transfer in patients with high risk of ovarian hyperstimulation syndrome after all blastocysts cryopreservation

作　　者：罗丹[1] 丁晓芳[1] 李璐璐[1] 舒德峰[1] 朱燕[1] 钟少红[1] 高颖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科生殖中心,武汉430022

出　　处：《临床急诊杂志》2016年第9期685-687,共3页Journal of Clinical Emergency

摘　　要：目的:观察卵巢过度刺激综合征(OHSS)患者行全胚冷冻后,择期进行解冻移植(FET)的临床结局,探讨其临床应用价值。方法:回顾性分析从2014-01-2014-12在我院生殖中心行常规体外受精-胚胎移植(IVFET)助孕治疗且有OHSS高风险的患者共187例,根据其移植时机分为为2组:A组为新鲜囊胚移植组72例;B组为全囊胚冷冻后择期解冻移植组115例。比较2组间的临床特征、促排卵情况、胚胎情况、妊娠结局及OHSS发生情况。结果:2组间的临床特征、促排卵情况、胚胎情况、早期流产率差异均无统计学意义。而2组间的临床妊娠率(45.8%vs.72.2%)和种植率(30.8%vs.52.8%)差异均有统计学意义(P<0.05)。OHSS发生率A组为8.33%,B组为0.87%,2组间的差异有统计学意义(P<0.05)。结论:OHSS患者冷冻全部囊胚后择期行解冻胚胎移植可以获得良好的妊娠结局,是一项安全的预防卵巢过度刺激综合征的临床应用方案。Objective：To compare the clinical pregnancy outcomes between fresh embryo transfer and frozenthawed embryo transfer（FET）after all blastocyst vitrification in patients with high risk of ovarian hyperstimulation syndrome（OHSS）.Method：A retrospective analysis of 187 patients with high risk of OHSS undergoing IVF treatment cycle in our reproductive center from January 2014 to December 2014 was made.The patients were classified into two groups：group A including 72 patients with fresh blastocyst transfer and group B including 115 patients with frozen-thawed blastocyst transfer.The clinical features,pregnancy outcome,incidence of severe OHSS were compared between the two groups.Result：The clinical features had no significant difference between the two groups.The clinical pregnancy rate（45.8% vs.72.2%）,and implantation rate（30.8% vs.52.8%）in group B were significantly higher than those in group A（P〈0.05）,but no significantly difference was found in abortion rate.The incidence of OHSS in group B were significantly lower than that in group A（0.87% vs.8.33%）.Conclusion：FET after all blastocysts cryopreservation can achieve a good pregnancy outcome,which is a safe clinical application scheme for preventing OHSS.

关 键 词：卵巢过度刺激综合征 囊胚冷冻 解冻胚胎移植 

分 类 号：R711.75[医药卫生—妇产科学]