184例急性髓系白血病患者DA方案首次化疗后血小板输注调查  

Survey of platelet transfusion of 184 cases of acute myeloid leukemia undergoing first course of chemotherapy based on anthracycline and cytarabine

作　　者：韩冰[1] 杨欢[1] 段笑生 秦莉[1] 

机构地区：[1]四川大学华西医院输血科,四川成都610041

出　　处：《中国输血杂志》2016年第12期1358-1360,共3页Chinese Journal of Blood Transfusion

摘　　要：目的调查急性髓系白血病患者DA方案首次化疗后临床血小板输注情况及输血不良反应的发生率。方法收集病例的输血记录、输血科发血记录、患者住院病历输血不良反应记录、输血种类及输血量等,利用SPSS对相关数据进行分析处理。结果 184例患者共输注血小板668次;输注前血小板为(11.8±10.0)×109/L,输注后血小板(24.4±23.9)×109/L,患者血小板输注后较输注前计数显著上升(Z=15.975,P<0.05)。有26例出现不同程度出血,出血发生率为14.1%。血小板申请平均等待时间为1.5 d,严重出血病例没有发现因血小板输注延误造成。共出现24次输血不良反应,发生率为3.6%,其中发热非溶血性输血反应10例,过敏反应14例。结论血小板输注是急性髓系白血病化疗患者重要的支持治疗,应严格掌握输注指征,综合评价患者出血状况等临床因素,从而提高输注有效率,减少输血不良反应。Objective To analyze the platelet transfusion and incidence of transfusion reactions in patients with acutemyeloid leukemia undergoing first course of chemotherapy based on anthracycline and cytarabine. Methods Eligible patients were screened from 2011 to 2013. Blood components transfused and transfusion reactions were analyzed. Results A total of 184 patients received 668 times of platelet transfusion. The platelet count prior to and following the transfusion was （ 11.8±10. 0）×10^9/L and （24.4±23.9） × 10^9/L, respectively （ Z = 15. 975, P〈0. 05）. Transfusion reactions occurred in 24 cases, of which 10 cases were non hemolytic febrile transfusion re- actions and 14 cases were anaphylactic reactions. Conclusion Platelet transfusion is an important supportive care for pa- tients with acute myeloid leukemia （AML） undergoing chemotherapy. A strict threshold should be taken and patients＂ clinical characteristics should be considered to improve transfusion efficiency and reduce incidence of transfusion reactions.

关 键 词：白血病 血小板输注 疗效 输血不良反应 

分 类 号：R331.143[医药卫生—人体生理学] R457.13[医药卫生—基础医学]