小剂量阿司匹林对妊娠期高血压的预防作用  

Preventive effect of low dose aspirin on the pregnancy induced hypertension

作　　者：林岱华[1] 毛邱娴[1] 周敬珍[1] 高祯[1] 

机构地区：[1]广东省第二人民医院产科,广东广州510317

出　　处：《中国医药科学》2016年第19期81-83,共3页China Medicine And Pharmacy

摘　　要：目的探讨小剂量阿司匹林对妊娠期高血压的预防作用,为临床治疗妊娠期高血压提供有效的途径。方法选取2015年1月-2016年5月我院所收治的有妊娠高血压高危因素孕妇180例,随机分成观察组和对照组,每组患者90例,观察组患者给予小剂量阿司匹林进行治疗,对照组给予安慰剂进行治疗。比较两组患者妊娠期高血压发生率、孕妇产后出血量、新生儿低体重发生情况和新生儿窒息发生率等因素。结果对照组的妊娠期高血压发生率为41.1%,显著高于观察组的妊娠期高血压发生率13.3%,观察组孕妇中重度、中度和轻度妊娠期高血压发生率均显著低于对照组,差异有统计学意义（P〈0.05）;两组孕妇产后出血量和出血率比较差异无统计学意义（P〉0.05）;观察组和对照组新生儿低体重发生率和窒息发生率分别为3.3%、1.1%和8.9%、6.7%,观察组新生儿低体重和窒息发生率显著较低,差异有统计学意义（P〈0.05）。结论小剂量阿司匹林能很好的治疗妊娠期高血压,降低妊娠期高血压的发生率,对新生儿没有危害,值得在临床上推广。Objective To explore the effect of low-dose aspirin for the prevention of pregnancy induced hypertension, to provide an effective way for the clinical treatment of gestational hypertension. Methods 180 cases of pregnancy pregnant women with high risk factors which cured in our hospital from January 2015 to May 2016 were selected and randomly divided into observation group and control group with 90 cases in each. Patients in observation group were given small dose aspirin treatment, and patients in control group were given placebo treatment. Gestational hypertension incidence, postpartum hemorrhage volume, low birth weight occurs and neonatal asphyxia rate and other factors of the two groups were compared. Results Pregnancy hypertension incidence rate of control group was 41.1%, which was significantly higher than that in the observation group with 13.3%. The omcodemce rate in observation group of moderate to severe, moderate and mild pregnancy induced hypertension pregnant women was significantly lower than that in control group. The difference had statistical significance（P〈0.05）. There was no significant difference between the two groups on pregnant women＇s postpartum hemorrhage volume and bleeding rate（P〉0.05）. Low birth weight incidence rate and the asphyxia rates of observation group and the control group were 3.3%, 1.1% and 8.9%, 6.7% respectively. In the observation group, the incidence of low birth weight and asphyxia was significantly lower, and the difference was statistical significance（P〈0.05）. Conclusion Low dose aspirin is a good treatment of pregnancy induced hypertension. It can reduce the incidence of pregnancy induced hypertension. And it has no harm to the newborn. So it is worth promoting in clinical.

关 键 词：阿司匹林 妊娠期高血压 预防 并发症 

分 类 号：R714.24[医药卫生—妇产科学]