阿加曲班联合依达拉奉治疗心房颤动合并脑栓塞的临床效果  

Clinical effect of Argatroban combined with Edaravone in the treatment of atrial fibrillation complicated with cerebral embolism

作　　者：黄春[1] 朱飞[1] 胡细灰[1] HUANG Chun ZHU Fei HU Xi-hui(Department of Neurology,Pingxiang City People＇s Hospital in Jiangxi Province,Pingxiang 337000,Chin)

机构地区：[1]江西省萍乡市人民医院神经内科,江西萍乡337000

出　　处：《中国当代医药》2016年第36期39-41,共3页China Modern Medicine

摘　　要：目的 探讨阿加曲班联合依达拉奉治疗心房颤动（房颤）合并脑栓塞的临床效果。方法 选取我院2014年3月~2016年5月收治的76例房颤合并脑栓塞患者。根据动态随机化原则,将患者分为研究组与对照组,每组38例。对照组患者使用低分子肝素治疗,研究组患者给予阿加曲班联合依达拉奉进行治疗,比较两组患者治疗前后的神经功能缺损（NIHSS）评分、日常生活活动能力量表（Barthel）评分以及凝血指标。结果 两组治疗前的NIHSS评分、Barthel评分差异无统计学意义（P〉0.05）,研究组治疗后的NIHSS评分[（9.15±2.12）分]、Barthel评分[（76.57±14.23）分],与对照组[（15.47±4.35）、（58.45±12.31）分]比较,优势较大（P〈0.05）。两组治疗前的凝血指标差异无统计学意义（P〉0.05）,研究组治疗后的凝血指标较对照组优势更明显（P〈0.05）。结论 阿加曲班联合依达拉奉治疗房颤合并脑栓塞能有效改善患者的神经功能缺损情况,提高其日常生活活动能力,改善凝血指标,在临床上可以广泛推广。Objective To explore the Clinical efficacy of Argatroban combined with Edaravone in the treatment of atrial fibrillation complicated with cerebral embolism.Methods 76 patients with atrial fibrillation and cerebral embolism admitted into our hospital from March 2014 to May 2016 were selected.Based on dynamic random classification,they were divided into research group （n=38） and control group （n=38）.The patients in the control group were treated with Low Molecular Weight Heparin and the patients in the research group were treated with Argatroban combined with Edaravone.The score of national institutes of health stroke scale （NIHSS）,Barthel score of activities of daily living,and coagulation indicator between two groups were compared.Results There was no statistical difference in NIHSS score or Barthel score between two groups before treatment （P〉0.05）.After therapy, the score of NIHSS was （9.15±2.12） points, and Barthel score was （76.57±14.23） points,which caught great superiority in comparison with those in the control group [（15.47±4.35） points,（58.45±12.31） points] （P〈0.05）.No great difference was displayed in the coagulation indicator before treatment （P〉0.05）,but after therapy,the advantage was greater in the research group compared with that in the control group （P〈0.05）.Conclusion Argatroban combined with Edaravone in the treatment of atrial fibrillation complicated with cerebral embolism can effectively improve neurologic impairment,ability of daily life activities,as well as coagulation indicator,which is worthy of Widespread promotion in clinic.

关 键 词：阿加曲班 依达拉奉 房颤 脑栓塞 凝血指标 

分 类 号：R541.7[医药卫生—心血管疾病]