吲哚美辛栓预防ERCP术后胰腺炎及高淀粉酶血症临床效果研究  

Comparison of Preventive Effect of Indomethacin on Post-ERCP Pancreatitis and Hyperamylasemia

作　　者：詹翔[1] 周玉保[1] 金树[1] 张道权[1] 郝睿[1] 谢菁[1] ZHAN Xiang ZHOU Yu-bao JIN Shu et al(Endoscopy Center and Endoscopy Research Institute, the Second Hospital of Anhui Medical University,Hefei 230022, Chin)

机构地区：[1]安徽医科大学第二附属医院内镜中心,合肥230601

出　　处：《肝胆外科杂志》2016年第6期409-412,共4页Journal of Hepatobiliary Surgery

摘　　要：目的观察并比较吲哚美辛栓预防经内镜逆行性胰胆管造影术（ERCP）后胰腺炎及高淀粉酶血症的临床效果。方法将2013年6月～2015年6月间本院内镜中心收治的204例接受ERCP诊治患者随机分为2组：吲哚美辛组于术前30min经直肠给与吲哚美辛栓剂100mg，对照组不予任何预防药物。检测所有患者术前、术后6h、12h、24h血清淀粉酶水平，比较2组患者ERCP术后胰腺炎（PEP）和高淀粉酶血症发生率，观察不良反应。结果2组患者ERCP术前血清淀粉酶均为正常值。术后6h、12h、24h血清淀粉酶水平与术前比较均升高，两组差异有统计学意义（P〈0．05）。吲哚美辛栓组、对照组PEP发生率分别为4．00％、18．37％，差异有统计学意义（χ2=3．810，P〈0．05）；吲哚美辛组、对照组ERCP术后高淀粉酶血症发生率分别为32．00％、55．10％，差异有统计学意义（χ2=5．437，P〈0．05）。吲哚美辛组未出现严重不良反应。结论ERCP术前预防性直肠应用吲哚美辛栓可有效降低PEP和高淀粉酶血症的发生率，且安全性好。Objective To compare the preventive effect of ~ndomethacin on post-ERCP pancreatitis （PEP） and hyperamy- lasemia. Methods A total of 204 patients were enrolled to receive endoscopic retrograde cholangiopancreatograph （ERCP）. All pa- tients were divided into two groups： indomethacin group （anal indomethacin ） or control group （no special medication）. Test serum amylase of the patients preoperative and 6h 12h 24h hours after operation. Incidence of PEP and hyperamylasemia were observed and compared between the two groups. Result The incidences of PEP and hyperamylasemia in indomethacin group were significantly lower than those in control group （P 〈 0.05 ）. No severe adverse effects were observed. Conclusion Indomethacin can safely effectively prevent post-ERCP pancreatitis and hyperamylaemia.

关 键 词：内窥镜逆行胰胆管造影术(PEP) 吲哚美辛栓 胰腺炎 高淀粉酶血症 

分 类 号：R658[医药卫生—外科学]