正常志愿者情绪图片刺激MR脑功能成像性别差异的研究  

Gender Differences in Healthy Volunteers Stimulated by Emotional Pictures Through Functional MRI

作　　者：高丽[1] 史大鹏[1] 王恩峰[1] 管民[1] 李中林[2] 李永丽[1] GAO Li SHI Dapeng WANG Enfeng GUAN Min LI Zhonglin LI Yongli(Department of Radiology, People＇s Hospital of Zhengzhou University, Zhengzhou 450003, Chin)

机构地区：[1]郑州大学人民医院放射科,河南郑州450003 [2]解放军信息工程大学,河南郑州450002

出　　处：《中国医学影像学杂志》2016年第12期890-894,共5页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金面上项目(81271534);河南省科技厅科技攻关项目(132102310063);河南省卫生厅科技攻关项目(201202023)

摘　　要：目的探讨健康志愿者在情绪图片刺激下脑功能的性别差异。资料与方法收集2014年11-12月河南职工医学院20名健康在校大学生志愿者的脑功能数据进行前瞻性研究,其中男12例,女8例。采用中国情绪图片系统(CAPS)作为刺激源,选取正性、中性、负性图片各30幅,男性组与女性组选用相同的情绪图片。每名志愿者随机给予正性、中性及负性图片刺激,同时进行MR脑功能成像扫描。对脑功能成像进行后处理及统计学分析,分别得到不同性别在情绪图片刺激下激活的脑区及差异脑区。结果在负性情绪图片刺激下,男性激活右侧杏仁体及右侧前额叶,女性激活双侧杏仁体及双侧前额叶;正性情绪图片刺激下,男性组激活双侧颞叶及双侧楔叶,女性组激活双侧楔叶,差异有统计学意义(P<0.05)。不同性别组间比较显示,负性情绪刺激下,女性相对男性激活增强脑区有左侧杏仁体、双侧前额叶、双侧楔前叶、右侧岛叶,差异有统计学意义(P<0.05);男性相对女性无激活增强脑区。正性情绪刺激下,女性相对男性左侧前额叶激活增强,男性相对女性左侧颞叶激活增强,差异有统计学意义(P<0.05)。结论不同性别健康志愿者在情绪刺激下激活脑区存在差异性。尤其在负性情绪刺激下,女性激活脑区较男性多且激活程度增强,进一步证实女性对于负性情绪的反应更强烈。Purpose The study aimed to explore gender differences of brain activation in healthy volunteers under the stimulation of emotional pictures. Materials and MethodsThe cerebral functional imaging data of twenty healthy volunteers at Henan Medical College from Nov. 2014 to Dec. 2014 were prospectively studied（12 males and 8 females）. Emotional pictures（30 positive, 30 negative and 30 neutral pictures） from Chinese Affective Picture System（CAPS） were used randomly as visual stimuli for both males and females. Functional MRI was performed while each subject was stimulated by emotional pictures. The f MRI data were processed and the statistical analysis was performed to obtain the activated brain regions of males and females and to compare the gender differences. Results Under the stimuli of negative emotional pictures, bilateral temporal lobe, bilateral cuneus in men and bilateral cuneus in women were activated under the stimuli of positive emotional pictures（P〈0.05）. Compared with men, increased activation of left amygdala, bilateral prefrontal gyrus, bilateral precuneus and right insula were observed in women under the stimuli of negative pictures. The differences were statistically significant（P〈0.05）. Compared with women, no cerebral region was more activated in men under the stimuli of negative pictures. Under the stimuli of positive emotional pictures, the left prefrontal gyrus in women was more activated than that in men whilst the left temporal lobe in men was more activated than that in women. The differences were statistically significant（P〈0.05）. Conclusion Gender differences of activated cerebral regions under stimuli of emotional pictures do exist in healthy volunteers. In particular, more cerebral regions and increased activation were observed in women compare to men, which demonstrates that women response stronger to negative emotion.

关 键 词：磁共振成像 情绪 性别因素 脑功能成像 志愿工作者 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741.04[医药卫生—诊断学]