重组EPO辅助治疗对重度颅脑损伤患者神经功能恢复、炎症反应、红细胞糖代谢的影响  

Effect of adjuvant recombinant EPO therapy on neural functional recovery,inflammation and erythrocyte glucose metabolism in patients with severe craniocerebral injury

作　　者：鲁增[1] 龙振海[1] 

机构地区：[1]辽宁省阜新市中心医院神经外科一病房,辽宁阜新123000

出　　处：《海南医学院学报》2017年第2期213-216,共4页Journal of Hainan Medical University

基　　金：辽宁省教育厅基金资助项目(L2010216)~~

摘　　要：目的:研究重组EPO辅助治疗对重度颅脑损伤患者神经功能恢复、炎症反应、红细胞糖代谢的影响。方法:选择2013年5月~2016年3月期间在辽宁省阜新市中心医院就诊的78例重型颅脑损伤患者并随机分为EPO组和对照组,分别接受重组人促红细胞生成素(rhEPO)联合常规治疗和常规治疗。治疗前和治疗后7d、14d时,分别评估脑组织缺氧程度、神经损伤程度、炎症反应程度以及红细胞糖代谢状况。结果:两组患者治疗后7d、14d时的PbtO_2水平以及血清NGB、HGB含量以及PFK活性均显著高于治疗前,血清NF-H、NF-L、NF-M、NSE、S100β、IL-2、P-选择素、sICAM-1含量以及G-6PD、AR活性均显著低于治疗前;EPO组患者治疗后7d、14d时的PbtO_2水平以及血清NGB、HGB含量以及PFK活性均显著高于对照组,血清NF-H、NF-L、NF-M、NSE、S100β、IL-2、P-选择素、sICAM-1含量以及G-6PD、AR活性均显著低于对照组。结论:重组EPO辅助治疗能够通过抑制炎症反应、改善红细胞糖代谢的方式来减轻重度颅脑损伤患者的神经损伤程度。Objective：To study the effect of adjuvant recombinant EPO therapy on neural functional recovery,inflammation and erythrocyte glucose metabolism in patients with severe craniocerebral injury.Methods：A total of 78 patients with severe craniocerebral injury treated in our hospital between May 2013 and March 2016 were selected and randomly divided into the EPO group and control group who received recombinant human erythropoietin（rhEPO）combined with conventional therapy and conventional therapy respectively.Before treatment as well as 7d and 14 d after treatment,the degree of brain tissue hypoxia,nerve injury and inflammation as well as erythrocyte glucose metabolism were evaluated respectively.Results：PbtO_2 levels,serum NGB and HGB content as well as PFK activity of both groups 7d and 14 d after treatment were significantly higher than those before treatment while serum NF-H,NF-L,NF-M,NSE,S100β,IL-2,P-selectin and sICAM-1 content as well as G-6PD and AR activity were significantly lower than those before treatment;PbtO_2 levels,serum NGB and HGB content as well as PFK activity of EPO group 7d and 14 d after treatment were significantly higher than those of control group while serum NF-H,NF-L,NF-M,NSE,S100β,IL-2,P-selectin and sICAM-1 content as well as G-6PD and AR activity were significantly lower than those of control group.Conclusions：Adjuvant recombinant EPO therapy can inhibit inflammation and improve erythrocyte glucose metabolism to reduce the nerve injury degree in patients with severe craniocerebral injury.

关 键 词：重型颅脑损伤 促红细胞生成素 脑氧代谢 炎症反应 红细胞糖代谢 

分 类 号：R614[医药卫生—麻醉学]