粒细胞集落刺激因子对心肌梗死患者PCI术后心功能及内皮功能的影响  

Effect of granulocyte colony-stimulating factor on the cardiac function and endothelial function in patients with myocardial infarction after PCI

作　　者：王蔚[1] 王越希 钟德超[1] 李丹[1] 陈茂[3] WANG Wei WANG Yue-xi ZHONG De-chao LI Dan CHEN Mao(Department of Vasculocardiology, Zigong First People＇s Hospital in Sichuan Province, Zigong City 643000, Sichuan Province, China Department of Oncology, Zigong First People＇s Hospital in Sichuan Province, Zigong City 643000, Sichuan Province, China Department of Cardiology, West China Hospital, Sichuan University, Chengdu City 610041, Sichuan Province, China)

机构地区：[1]四川省自贡市第一人民医院心血管内科,四川自贡643000 [2]四川省自贡市第一人民医院肿瘤科,四川自贡643000 [3]四川大学华西医院心脏内科,四川成都610041

出　　处：《海南医学院学报》2017年第4期456-459,共4页Journal of Hainan Medical University

基　　金：四川省医学会"施慧达"科研课题(SHD12-01)~~

摘　　要：目的:探讨粒细胞集落刺激因子(G-CSF)对心肌梗死患者经皮冠状动脉介入(PCI)术后心功能及内皮功能的影响。方法:收集2012年8月~2016年1月收治的急性心肌梗死患者76例,按照随机平行对照法分为观察组、对照组各38例。对照组接受PCI术治疗,观察组在PCI术后加入G-CSF治疗(5μg/kg,皮下注射,3次/d,持续5d)。治疗后2周,采用彩色多普勒超声仪检测心功能参数,采用放射免疫法检测血清心功能指标,采用酶联免疫吸附法(ELISA)测定血清内皮功能指标。结果:治疗前,两组血清心功能指标及内皮功能指标含量的差异无统计学意义。治疗后2周,观察组心输出量(CO)、每搏量(SV)水平显著高于对照组,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)水平低于对照组;观察组血清中心脏型脂肪酸结合蛋白(H-FABP)、氨基末端B型利钠肽前体(NT-proBNP)、半乳糖凝集素-3(Galectin-3)含量低于对照组,内皮素-1(ET-1)含量低于对照组,一氧化氮(NO)含量高于对照组。结论:G-CSF可增强心肌梗死患者的PCI术后心功能,同时优化血管内皮功能。Objective：To explore the effect of granulocyte colony-stimulating factor（G-CSF）on the cardiac function and endothelial function in patients with myocardial infarction after percutaneous coronary intervention（PCI）.Methods：A total of 76 patients with acute myocardial infarction treated in our hospital between August 2012 and January 2016 were collected and divided into observation group and control group（n=38）according to the randomized parallel control method.Control group of patients received PCI treatment,and observation group of patients received G-CSF treatment（5μg/kg,subcutaneous injection,3times/d,for 5d）after PCI.Two weeks after treatment,color Doppler diasonograph was used to detect cardiac function parameters,RIA method was used to detect serum cardiac function indexes,and enzyme-linked immunosorbent assay（ELISA）was used to detect serum endothelial function indexes.Results：Before treatment,differences in serum cardiac function index and endothelial function index levels were not statistically significant between two groups of patients.Two weeks after treat-ment,cardiac output（CO）and stroke volume（SV）levels of observation group were significantly higher than those of control group while left ventricular end-diastolic diameter（LVEDD）and left ventricular end-systolic diameter（LVESD）levels were lower than those of control group;serum heart-type fatty acid-binding protein（H-FABP）,N-terminal pro-B-type natriuretic peptide（NT-proBNP）and Galectin-3levels of observation group were lower than those of control group,endothelin-1（ET-1）level was lower than that of control group,and nitric oxide（NO）level was higher than that of control group.Conclusion：GCSF can enhance the cardiac function after PCI and also optimize the endothelial function in patients with myocardial infarction.

关 键 词：心肌梗死 粒细胞集落刺激因子 心功能 内皮功能 

分 类 号：R542.22[医药卫生—心血管疾病]