细菌鞭毛运动、黏附和免疫逃逸机制的研究进展  

Progress in the mechanism of bacterial flagellum motility,adhesion and immune escape

作　　者：许绵[1,2] 周明旭[1,2] 朱国强[1,2] 

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《中国兽医学报》2017年第2期369-375,380,共8页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(30571374;30771603;31072136;31270171);江苏高校优势学科建设工程资助项目;科技部转基因生物新品种培育重大专项资助项目(2014ZX08006-001B);国家农业部"948"计划重点资助项目(2011-G24)

摘　　要：鞭毛是细菌表面重要的附属结构之一,很长一段时间以来被认为仅负责细菌的运动。然而随着对鞭毛的结构以及致病性深入研究发现,鞭毛的运动性能够促进细菌与宿主的相互作用,鞭毛介导的黏附在几种动植物病原体对宿主的定植过程中起很重要作用,而促进鞭毛结合到不同宿主组织的特异性互作机制至今仍不清楚。鞭毛素单体的保守区是机体先天性免疫应答的有效诱导剂,能够诱导机体发生免疫应答,然而细菌也进化出多重策略来逃避免疫识别。现对近年来细菌鞭毛在动植物宿主环境中的作用作一综述,为更全面认识和研究鞭毛提供参考。Flagellum is one of the important accessory structures of the bacterial surface,which is considered to be only responsible for the movement of the bacteria. However,with the deep study on the structure of the flagella and pathogenic found that flagellum exercise can promote the interaction between bacterial flagella and host, flagella mediated adhesion plays an important role in several animal and plant pathogens to host the colonization process, and specific mechanism which promote the combination of flagella interaction to different host tissue was still not clear. The con- served region of the body is a effective inducer of innate immune response, which can induce im- mune response. However, the bacteria also evolved multiple strategies to avoid immune recognition. This review summarized the role of bacterial flora in the environment of animal and plant hosts,providing the basis for a more comprehensive understanding and research of the flagella.

关 键 词：细菌鞭毛 运动性 黏附 免疫逃避 

分 类 号：S852.61[农业科学—基础兽医学]