益生菌在儿童肝胆疾病的应用  

Application of probiotics in the liver and biliary diseases of children

作　　者：郭珊[1,2] 舒赛男[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,湖北武汉430030 [2]华中科技大学同济医学院附属武汉儿童医院,湖北武汉430015

出　　处：《中国实用儿科杂志》2017年第2期110-114,共5页Chinese Journal of Practical Pediatrics

摘　　要：益生菌是活的非致病性细菌,具有改善微生态环境、维持人类健康状态的作用。"肠-肝轴"提示肠道微生物和肝胆之间有着复杂的关系。肠腔内微生物种类和数量的改变,可以通过生成氨和内毒素等一系列机制损害肝功能。一些研究证实了益生菌对预防和治疗儿童肝胆疾病(如胆汁淤积性肝病、非乙醇性脂肪肝、肝硬化和肝移植等)具有积极作用。益生菌作为一种安全、相对价廉、非侵入性的治疗策略,可以改善不同类型肝胆疾病的病理生理进程,减轻症状,且未见明显副反应,具有良好的应用前景。Probiotics are live, nonpathogenic bacteria with the function of improving the micro-environment and promoting the heahh of the host. The ＂gut-liver axis＂ shows that there is complexed relationship between the liver/gallbaldder and gut mi- crobiota. Alterations of the type and amount of the micro-organisms in the intestinal tract can result in liver dysfunction due to the production of ammonia and endotoxin. Some studies have confirmed the positive influence of probiotic strains on the pre- vention and treatment of liver and biliary diseases in children, such as nonalcoholic fatty liver disease, cholestasis, cirrhosis, and liver transplantation. Probiotic therapy, as a safe, inexpensive and noninvasive treatment strategy, can alleviate and improve the pathophysiological courses and symptoms of different types of liver and biliary diseases without obvious side effects, which has great prospect of application.

关 键 词：益生菌 儿童 肝胆疾病 

分 类 号：R72[医药卫生—儿科]