常春藤皂苷元衍生物的合成  

The Derivatives of Hederagenin of Synthesis

作　　者：洪开文 董登祥[2] HONG Kaiwen DONG Dengxiang(Applied Medical Department, Vocational and Technical College of Anshun, Anshun 561000, China College of Pharmacy, GuiYang College of Traditional Chinese Medicine, Guiyang 550001, China)

机构地区：[1]安顺职业技术学院应用医药系,贵州安顺561000 [2]贵阳中医学院药学院,贵州贵阳550001

出　　处：《中国民族民间医药》2017年第2期22-27,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：贵州省科技攻关项目(编号:黔科合SY【2010】3016号)

摘　　要：目的:对常春藤皂苷元的3-OH、23-CH_2OH及28-COOH进行结构修饰,以改善其溶解性。方法:通过对其结构中羧基进行酯化、羟基进行乙酰化、醚化、苯甲酰化。结果:共合成了8个常春藤皂苷元衍生物,其中6个衍生物未见文献报道,并都通过MS、IR、1H-NMR、13C-NMR等确认结构。结论:对天然产物的结构修饰进行了探索,获得了天然产物常春藤皂苷元的一系列结构修饰产物。为下一步细胞活性筛选提供物质基础,也为中药新药的研发提供了一条途径。This study of the structural modification 3-OH or 23-CH2 OH or 28-COOH of hederagenin is to improve its solubility. Methods The experiment is carried out by esterification of the carboxyl hydroxyl its structure acetylation,etherification and benzoyl.Re-sutts A total of 8 the derivatives of hederagenin were synthesized,including 6 the derivatives of were not reported.Their structures were determined by MS,IR,1H-NMR,13C-NMR.Conclusion The structures of natural products of modifications are explored.These obtained that are series of natural products hederagenin structures of modification products.It’s not only providing the material basis for the next cell activity screening,but also can find a way the developments of traditional Chinese medicine new drugs are researched.

关 键 词：常春藤皂苷元 结构修饰 合成 天然产物 

分 类 号：R284.2[医药卫生—中药学]