蚕砂叶绿素水提物光动力疗法对痤疮丙酸杆菌体外抑制实验研究  

Inhibitory Effect of Silkworm Chlorophyll Extract Photodynamic Therapy on Propionibacterium Acnes

作　　者：施建新[1] 闵仲生[1] SHI Jianxin MIN Zhongsheng(Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China)

机构地区：[1]江苏省中医院,江苏南京210029

出　　处：《中国民族民间医药》2017年第2期41-43,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:评估蚕砂叶绿素水提物光动力疗法在体外对痤疮丙酸杆菌的抑制效应。方法:以96孔板为实验载体,加入痤疮丙酸杆菌,分为实验组、蚕砂组、细菌红光组及细菌组,采用半导体固态冷光源,进行光动力治疗。结果:1000mg/mL蚕砂联合光动力疗法组各浓度的培养皿中未见菌落产生,其余各蚕砂PDT组培养皿中未均见菌落产生。蚕砂组、细菌组、细菌红光组培养皿中均可见菌落产生。而对照组中痤疮丙酸杆菌生长未受抑制。结论:临床使用蚕砂叶绿素水提物联合光动力疗法治疗丙酸杆菌所致痤疮具有一定可行性,其疗效可在今后临床试验中进一步观察。Objective To evaluate the effect of silkworm chlorophyll extract photodynamic therapy on Propionibacterium acnes. Methods 96-well cell culture plates were used for experimental carriers and Propionibacterium acnes suspension was added to these wells,which were divided into experimental group and three control groups.With Semiconductor as the exctiation source.Results 1000mg/mL Silkworm-PDT group can completely inhibited the growth of each concentration of P.acnes,the rest Silkworm -PDT group can’ t completely inhibited the growth of each concentration of P.acnes.Silkworm groups,the group of bacteria and bacterial phototherapy groups can’ t completely inhibited the growth of each concentration of P.acnes.The growth of P.acnes was not inhibi-ted in three control groups.Conclusion The experimental results provide the experimental basis for the clinical use of silkworm chloro-phyll extract in the treatment of acne.

关 键 词：蚕砂叶绿素水提物 光动力疗法 痤疮丙酸杆菌 体外实验 

分 类 号：R246.7[医药卫生—针灸推拿学]