阿托伐他汀对于慢性硬脑膜下血肿钻孔引流术后并发症的影响  

Effect of atorvastatin on postoperative complications after the burr hole drainage of chronic subdural hematoma

作　　者：胡文富[1] 李军[1] 杨非[1] 孙家合[1] 宋怡诚[1] Hu Wenfu Li Jun Yang Fei Sun Jiahe Song Yicheng(Department of Neurosurgery, the First People＇s Hospital of Hefei, the Third Affiliated Hospital of Anhui Medical University, Hefei 230061, China)

机构地区：[1]合肥市第一人民医院安徽医科大学第三附属医院神经外科,230061

出　　处：《中国医师进修杂志》2017年第1期56-59,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的：探讨阿托伐他汀对于慢性硬脑膜下血肿（CSDH）术后并发症的影响。方法回顾性分析172例CSDH并且行钻孔引流治疗患者的临床资料，其中82例服用阿托伐他汀（阿托伐他汀组），90例未服用阿托伐他汀（对照组），比较两组术后并发症发生情况。结果两组均随访至术后6个月，对照组总术后并发症发生率明显高于阿托伐他汀组[47.78%（43/90）比31.71%（26/82）]，其中对照组硬脑膜下血肿复发率、硬脑膜下积液发生率均明显高于阿托伐他汀组[22.22%（20/90）比8.54%（7/82）、28.89%（26/90）比12.20%（10/82）]，差异有统计学意义（P＜0.05）。两组颅内积气、急性硬脑膜外及硬脑膜下血肿发生率和引流管导致脑损伤发生率比较差异无统计学意义（P＞0.05）。结论阿托伐他汀可显著改善CSDH患者手术预后，尤其可降低硬脑膜下血肿复发率及硬脑膜下积液发生率。Objective To explore the effect of atorvastatin on postoperative complications after the burr hole drainage of chronic subdural hematoma （CSDH）. Methods The clinical data of 172 CSDH patients who had underwent the burr hole drainage were retrospectively analyzed. Among them 82 patients were given atorvastatin （atorvastatin group）, and 90 patients were not given atorvastatin （control group）. The postoperative complications were compared between 2 groups. Results All patients were followed up for 6 months. The total incidence of postoperative complications in control group was significantly higher than that in atorvastatin group：47.78%（43/90） vs. 31.71%（26/82）, and the recurrent rate of subdural hematoma and incidence of subdural effusion in control group were significantly higher than those in atorvastatin group： 22.22% （20/90） vs. 8.54% （7/82） and 28.89% （26/90） vs. 12.20%（10/82）. There were statistical differences （P〈0.05）. There were no statistical difference in the incidences of pneumocephalus, acute epidural/subdural hematoma and brain damage induced by drainage tube （P〉0.05）. Conclusions Atorvastatin can improve the prognosis of CSDH patients, especially in reducing the incidence of recurrent subdural hematoms and subdural effusion.

关 键 词：血肿 硬膜下 慢性 引流术 手术后并发症 阿托伐他汀 

分 类 号：R651.1[医药卫生—外科学]