犬瘟热病毒体外感染人源细胞的分子研究进展  

How the Canine Distemper Virus Infects Human Cells at the Molecular Level in Vitro

作　　者：曹雪峰[1] 田一男 黄祥明 邱薇[3] 杨颜铱 弓超[1] 杨奎兴 袁博 彭广能[1] 钟志军[1] CAO Xuefeng TIAN Yinan HUANG Xiangming QIU Wei YANG Yanyi GONG Chao YANG Kuixing YUAN Bo PENG Guangneng ZHONG Zhijun(College of Veterinary Medicine, Sichuan Agricultural University ,Yaan 625014, China Chengdu Research Base of Giant Panda Breeding, Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu 610081, China Center for Disease Control and Prevention of Chengdu Military Region, Kunrning 650118, China)

机构地区：[1]四川农业大学动物医学院动物疫病与人类健康四川省重点实验室,雅安625014 [2]成都大熊猫繁育研究基地四川省濒危野生动物保护生物学省部共建实验室,成都610081 [3]成都军区疾病控制预防中心,昆明650118

出　　处：《病毒学报》2017年第1期116-122,共7页Chinese Journal of Virology

基　　金：国家自然科学基金资助项目(项目号:31000548);题目:布鲁氏菌比较基因组与微进化研究;四川省教育厅重点资助项目(项目号:13ZA0263);题目:四川地区伴侣犬布鲁氏菌病的血清学及分子流行病学调查;成都大熊猫繁育研究基金会项目(项目号:CPF2015-4);题目:西南地区圈养大熊猫弓形虫和肠道寄生虫感染动态调查研究

摘　　要：犬瘟热病毒(Canine distemper virus,CDV)是一种主要通过呼吸道传播对犬科动物造成严重危害的烈性传染病。近年随着CDV在灵长类动物中暴发,研究者开始关注CDV是否具有潜在感染人的风险。目前虽然无直接证据证明CDV可在人体内定殖,但CDV在体外能感染人源细胞,且人体内CDV关键受体SLAM和Nectin-4与灵长类动物具有极高的同源性,因此我们必须高度重视CDV对人类的潜在威胁。本文对CDV分子结构特征、CDV感染宿主靶细胞过程、CDV入侵宿主所需关键受体以及CDV野毒株体外感染人源细胞等方面进行综述,分析CDV对人是否具有潜在感染的风险。Infection by the canine distemper virus （CDV） results in a fulminating infectious disease that causes serious harm to dogs. With breaking of the CDV into primates, some researchers wonder if the CDV will cause a serious infection in humans. To better understand the potential of the CDV to infect humans, the molecular characteristics of the CDV, how it infects target cells in the host, the key receptors involved in infection, and infection of human cells in vitro were assessed in this review. There is no direct evidence that CDV can colonize and grow in humans. Two key receptors, SLAM and nectin-4, in humans and primates have high identity, and the CDV can infect human cells in vitro. Therefore, we must pay close attention to the potential threat of infection by the CDV in humans.

关 键 词：犬瘟热病毒(CDV) 烈性传染病 受体 体外感染人源细胞 

分 类 号：S852.65[农业科学—基础兽医学]