高效液相色谱法测定对甲苯磺酸的纯度  

Determination of the Purity of p-Toluenesulfonic Acid by HPLC

作　　者：丁军委[1] 郑建慧 王玉娥[1] 

机构地区：[1]青岛科技大学,山东青岛266042

出　　处：《当代化工》2017年第1期179-181,共3页Contemporary Chemical Industry

摘　　要：建立了高效液相色谱法测定对甲苯磺酸纯度的方法。色谱柱为ODS柱,流动相为乙腈:水=1.5:1(体积比),流速为0.8 m L/min,检测波长为254 nm,进样溶液p H为7~8(用氨水中和)。标准曲线的相关系数为0.999 5,线性范围0.015~1.5 mg/m L。相对标准偏差为1.32%,最低检出限为0.01 mg/m L。该方法具有简单、快速、准确的优点。A high performance liquid chromatographic method for the determination of the purity of p-toluenesulfonic acid was developed. The column was ODS column. The mobile phase was acetonitrile and water whose volume ratio was 1.5： 1 with a flow rate of 0.8 m L/min.The detection wavelength was set as 254 nm.The injection solution PH was 7＇s8（neutralized with ammonia）. The correlation coefficient for the standard curve was 0.099 5,the linear range was 0.015＇s1.5 mg/m L. The relative standard deviation was 1.32%, the lowest detection limit was 0.01 mg/m L. The method is simple, fast and accurate.

关 键 词：高效液相色谱 对甲苯磺酸 氨水 

分 类 号：O657[理学—分析化学]