黑龙江省一起牛曼氏杆菌病疫情的暴发调查  

An Outbreak Investigation on Bovine Mannheimiosis in Heilongjiang Province

作　　者：刘春国[1] 郭东春[1] 刘大飞[1] 曹伟伟[2] 王靖飞[1] 韦欣捷[3] 曲连东[1] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,黑龙江哈尔滨150069 [2]河南省动物疫病预防控制中心,河南郑州450008 [3]中国动物卫生与流行病学中心,山东青岛266032

出　　处：《中国动物检疫》2017年第2期1-4,共4页China Animal Health Inspection

基　　金：联合国粮农组织-中国兽医现场流行病学培训项目;科技部科技基础性工作专项(2012FY111000)

摘　　要：2015年11月14日至12月14日,黑龙江省某县多个村从外县购入的牛发生不明原因的急性死亡。发病牛主要表现呼吸道症状,从发病到死亡的时间为几小时到数天不等,病死牛剖检可见严重肺炎病变。为揭示疫病暴发的主要病因,提供防控建议,结合现场流行病学调查和实验室诊断,对该次疫情开展了调查。调查结果显示:此次疫情波及6个村,发病牛多为1岁左右;时值气候寒冷;疫情发生前1周左右,有牛调运史。实验室诊断结果显示,采集的样本中均含有未分类的曼氏杆菌,其对氨苄西林和环丙沙星耐药,而对头孢曲松敏感。最终确认本次疫情是由牛群调运、寒冷气候和年龄等风险因素相互作用,诱发曼氏杆菌的内源性感染所致。During November 14 th to December 14 th,2015,an acute death of unknown origin occurred in cattle purchased from another county in several villages of Heilongjiang province. These diseased cattle mainly showed respiratory symptoms and the time periods of morbidity to death were various（ranging from several hours to a couple of days）. By autopsy diagnosis,severe pneumonia was found. In order to fi nd out the cause and provide suggestions for its prevention and control,an investigation was conducted by fi eld epidemiological survey in combination with laboratory diagnosis. Investigation results showed this outbreak covered 6 villages,most diseased cattle were around the age of 1. In addition,the weather was cold during the epidemic period. And about a week before outbreak,the cattle had been allocated and transported. Based on the results of laboratory diagnosis,it was found that unclassifi ed Mannkimia existed in all the collected samples,these strains were resistant to both Ampicillin and Ciprofl oxacin,but sensitive to Ceftriaxone. Eventually,the cause of death was confi rmed as endogenous infection of Mannkimia,which was induced by interaction of major risk factors,including allocation and transportation of the cattle,their ages and the cold weather,etc.

关 键 词：牛 曼氏杆菌 流行病学 暴发调查 耐药性 

分 类 号：S851.313[农业科学—预防兽医学]